Combined NMES and Low-Intensity Resistance Training in Older Adults
Official title: Combined Effects of Neuromuscular Electrical Stimulation and Low-intensity Resistance Training on Muscle Strength, Girth, and Physical Endurance in Geriatric Population
Run by Riphah International University · NCT07646405 · Data updated 2026-11-12
This study tests whether pairing electrical stimulation with light resistance training helps older adults gain muscle strength and endurance.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years to 85 Years |
| Sex | All |
| Enrollment | 44 (estimated) |
| Sponsor | Riphah International University Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | May 17, 2026 |
| Main results expected | July 6, 2026 |
| Study ends | August 6, 2026 |
| Registry record updated | June 12, 2026 |
| Trial ID | NCT07646405 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 65 to 85 with low calf muscle mass, able to walk independently, and able to complete basic functional tests, without severe medical conditions.
✕Probably not a fit
Individuals with contraindications to NMES or resistance training, significant cognitive impairment, musculoskeletal issues, or severe cardiovascular disease may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled study will compare a combined NMES and low-intensity resistance training program to a control condition in adults aged 65 to 85 with debility. Participants will undergo baseline and post-intervention assessments of muscle strength, muscle girth, and 6-minute walk endurance. NMES sessions will occur 2-3 times per week and LIRT sessions will occur 2-3 times per week over 4-5 weeks, targeting major limb muscles. Informed consent, demographic data collection, and standardized outcome measures will be used to evaluate the effects of the intervention.
Why it matters
Potential benefit: If successful, the approach could improve muscle strength and endurance in frail older adults, potentially aiding daily activities.
How similar studies have gone: Previous studies in similar populations suggest NMES and resistance training can improve strength, supporting this combined approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:• Age: 65 to 85 (35) * Both male and female will be added(29) * Patients with low calf muscle mass \<31.5 cm for females and \<33.5 cm for males will be included in this study(36). * Participants able to complete the Five Times Sit-to-Stand Test in ≤ 10 seconds (men) or ≤ 11 seconds (women)(37). * Participants must have ability to walk independently and absence of severe medical conditions(29). * Participants who takes \> 12 seconds to complete TUG will be included in this study(38 Exclusion Criteria:• Participants with contraindications to NMES or RT, such as pacemakers or severe cardiovascular disease(29). * Participants with a MoCA score of less than 26 will be excluded to ensure adequate cognitive ability to comprehend and follow the study protocol, including exercise and neuromuscular stimulation procedures (39). * Participants with any musculoskeletal issues will be excluded from this study(35). * Participants with neuromuscular disorders that may affect muscle strength or function(29).
Where it's running
- Lahore, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Sabiha Arshad, MS — Riphah International University
- Study coordinator: Isha butt butt, DPT
- Email: ishamb.09876@gmail.com
- Phone: 03324390215
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.