Clinical trial Recruiting at 1 site Interventional Ages 65 to 85

Combined NMES and Low-Intensity Resistance Training in Older Adults

Official title: Combined Effects of Neuromuscular Electrical Stimulation and Low-intensity Resistance Training on Muscle Strength, Girth, and Physical Endurance in Geriatric Population

Run by Riphah International University · NCT07646405 · Data updated 2026-11-12

This study tests whether pairing electrical stimulation with light resistance training helps older adults gain muscle strength and endurance.

Quick facts

Study typeInterventional
Ages65 Years to 85 Years
SexAll
Enrollment44 (estimated)
SponsorRiphah International University
Academic / other
Locations1 site (Lahore, Punjab Province)
StatusRecruiting
StartedMay 17, 2026
Main results expectedJuly 6, 2026
Study endsAugust 6, 2026
Registry record updatedJune 12, 2026
Trial IDNCT07646405 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 65 to 85 with low calf muscle mass, able to walk independently, and able to complete basic functional tests, without severe medical conditions.

Probably not a fit

Individuals with contraindications to NMES or resistance training, significant cognitive impairment, musculoskeletal issues, or severe cardiovascular disease may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled study will compare a combined NMES and low-intensity resistance training program to a control condition in adults aged 65 to 85 with debility. Participants will undergo baseline and post-intervention assessments of muscle strength, muscle girth, and 6-minute walk endurance. NMES sessions will occur 2-3 times per week and LIRT sessions will occur 2-3 times per week over 4-5 weeks, targeting major limb muscles. Informed consent, demographic data collection, and standardized outcome measures will be used to evaluate the effects of the intervention.

Why it matters

Potential benefit: If successful, the approach could improve muscle strength and endurance in frail older adults, potentially aiding daily activities.

How similar studies have gone: Previous studies in similar populations suggest NMES and resistance training can improve strength, supporting this combined approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:• Age: 65 to 85 (35)

* Both male and female will be added(29)
* Patients with low calf muscle mass \<31.5 cm for females and \<33.5 cm for males will be included in this study(36).
* Participants able to complete the Five Times Sit-to-Stand Test in ≤ 10 seconds (men) or ≤ 11 seconds (women)(37).
* Participants must have ability to walk independently and absence of severe medical conditions(29).
* Participants who takes \> 12 seconds to complete TUG will be included in this study(38

Exclusion Criteria:• Participants with contraindications to NMES or RT, such as pacemakers or severe cardiovascular disease(29).

* Participants with a MoCA score of less than 26 will be excluded to ensure adequate cognitive ability to comprehend and follow the study protocol, including exercise and neuromuscular stimulation procedures (39).
* Participants with any musculoskeletal issues will be excluded from this study(35).
* Participants with neuromuscular disorders that may affect muscle strength or function(29).

Where it's running

  • Lahore, Punjab Province, Pakistan Recruiting

Study contacts

  • Principal investigator: Sabiha Arshad, MS — Riphah International University
  • Study coordinator: Isha butt butt, DPT
  • Email: ishamb.09876@gmail.com
  • Phone: 03324390215

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.