Improving recovery in elderly patients with frailty undergoing surgery for digestive cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of a multicomponent prehabilitation program on elderly patients with frailty who are scheduled for major surgery due to digestive cancer. The program includes preoperative nutritional optimization and exercise training, as well as postoperative rehabilitation. By addressing frailty and malnutrition, the study aims to enhance recovery and improve both short-term and long-term outcomes for these vulnerable patients. The research focuses on understanding how these interventions can mitigate the adverse effects associated with frailty in surgical settings.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Age ≥65 years but \<90 years;
2. Scheduled to undergo major surgery for digestive cancer with an expected duration of 2 hours and longer, including cancers of esophagus, stomach, small intestine, colon, rectum, pancreas, liver, and biliary tract;
3. Clinical Frailty Scale ≥5;
4. Provide written informed consent.

Exclusion Criteria:

1. Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis;
2. Inability to communicate due to coma, profound dementia, or language barrier;
3. Inability to participate in preoperative rehabilitation due to paralysis, fracture or other movement disorder;
4. Inability to take oral diet due to preoperative gastrointestinal disease or other disease;
5. Severe heart dysfunction (left ventricular ejection fraction \<30% or New York Heart Association classification IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (undergoing dialysis before surgery), or American Society of Anesthesiologists classification of grade 4 or higher;
6. Other reasons that are considered unsuitable for study participation.

Where it's running

• Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD
• Email: wangdongxin@hotmail.com
• Phone: +8613910731903

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.