Colorectal Cancer Screening: a Blood Test for a Better Path to Colonoscopy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project explores whether blood markers related to oncofetal chondroitin sulphate (ofCS) can improve decision-making about colonoscopy in people undergoing CRC screening or in the cancer pathway. It combines ofCS analysis with other proteomics and metabolomics markers to see if the test improves accuracy beyond current methods like FIT. The study uses blood and stool samples to develop and validate a biomarker panel, aiming to raise AUC, sensitivity, and specificity for CRC detection and potentially identify adenomas earlier. It is conducted at Danish centers with adults undergoing colonoscopy, and no intervention beyond sample collection is planned. Initial results from related work show promising performance, supporting the potential to reduce unnecessary colonoscopies while maintaining cancer detection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients planned to undergo a colonoscopy either as part of the colorectal cancer screening programme due to a positive FIT or within a 'cancer patient pathway' for CRC at one of the study sites.
* Able to speak Danish, English, or other languages with sufficient interpretation provided by relatives.
* Able to give informed consent

Exclusion Criteria:

* Patients previously included in the study
* Patients known to be pregnant (pregnancy test not required)
* Non-resident in Denmark.

Where it's running

• Copenhagen University Hospital - North Zealand
  Hillerød, Denmark Recruiting
• Copenhagen University Hospital - Amager-Hvidovre
  Hvidovre, Denmark Recruiting

Study contacts

• Study coordinator: Claus Anders Bertelsen, PhD MD
• Email: claus.anders.bertelsen@regionh.dk
• Phone: +45 51 90 63 03

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• DISC-0974-201 for adults with IBD-related anemia

  This Phase 2 trial will test whether DISC-0974-201 helps adults with inflammatory bowel disease who have anemia driven by inflammation.

  Recruiting at 15 sites Phase 2 Disc Medicine, Inc · Birmingham, Alabama and 14 other locations · NCT07368972

• Non-invasive urine and stool tests for early colorectal cancer diagnosis

  This study is testing if special urine and stool tests can help find colorectal cancer early in patients who have already had a positive blood test.

  Recruiting at 2 sites Institut Investigacio Sanitaria Pere Virgili · Reus, Tarragona and 1 other locations · NCT06452745

• Using blood tests to detect and monitor colorectal cancer

  This study is testing if a blood test can help find and track colorectal cancer in patients who are about to have a colonoscopy.

  Recruiting Helse Nord-Trøndelag HF · Levanger · NCT06307938

• Using a microwave device to improve colonoscopy for detecting polyps

  This study is testing a new microwave device during colonoscopies to see if it can help doctors find more polyps that might be missed with regular methods.

  Recruiting MiWEndo Solutions S.L. · Barcelona · NCT05988645

• Comparing colonoscopy and stool testing for older adults with colon polyps

  This study is testing whether a simple stool test can be just as effective as colonoscopy for monitoring older adults with a history of colon polyps.

  Recruiting at 22 sites Dartmouth-Hitchcock Medical Center · Birmingham, Alabama and 23 other locations · NCT05612347

• New oral synbiotic formula to reduce colorectal adenoma recurrence

  This study is testing a new oral formula made of probiotics and prebiotics to see if it can help prevent the return of certain growths in the colon after they've been removed.

  Recruiting Chinese University of Hong Kong · Hohhot, Inner Mongolia and 1 other locations · NCT05592886

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.