Collection of tissue samples for vasculitis research
VCRC Tissue Biorepository Collection Protocol
This study is collecting tissue samples from patients with vasculitis to see if they can help researchers understand the disease better and find new ways to diagnose and treat it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Sex | All |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 8 sites (Boston, Massachusetts and 7 other locations) |
| Trial ID | NCT02967068 on ClinicalTrials.gov |
What this trial studies
This study aims to gather existing tissue specimens from patients enrolled in various Vasculitis Clinical Research Consortium (VCRC) studies. The collected specimens, which include biopsies from organs such as the kidney, lung, and skin, will be analyzed alongside clinical data to enhance understanding of vasculitis and related autoimmune diseases. The goal is to identify potential causes and develop new diagnostic tests and therapies for these conditions. Importantly, biopsies are not performed specifically for this study; rather, consent is sought to use samples collected during routine care.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who have been enrolled in other VCRC observational or interventional studies.
Not a fit: Patients who are unable to provide informed consent or are unwilling to allow their tissue to be used for research will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tests and therapies for patients suffering from vasculitis and related diseases.
How similar studies have performed: Other studies utilizing tissue specimens for research in autoimmune diseases have shown promise, indicating that this approach is supported by prior successful research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562). Exclusion Criteria: * Inability to give informed consent (or their guardians in the case of children) and to sign the consent form. * Unwilling to allow the use of their tissue for research.
Where this trial is running
Boston, Massachusetts and 7 other locations
- Brigham and Women's Hospital — Boston, Massachusetts, United States (Completed)
- Boston University School of Medicine — Boston, Massachusetts, United States (Completed)
- Cleveland Clinic — Cleveland, Ohio, United States (Completed)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (Recruiting)
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States (Completed)
- University of Utah — Salt Lake City, Utah, United States (Completed)
- St. Joseph's Healthcare — Hamilton, Ontario, Canada (Recruiting)
- University of Toronto Mount Sinai Hospital — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Katie Doyle
- Email: Kathryn.Logue@pennmedicine.upenn.edu
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.