Cognitive training for young adults with early psychosis
Remote State Representation in Early Psychosis
This study is testing if special brain training can help young adults with early psychosis improve their thinking and perception skills.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | University of Minnesota Academic / other |
| Locations | 1 site (Minneapolis, Minnesota) |
| Trial ID | NCT05538832 on ClinicalTrials.gov |
What this trial studies
This study investigates how cognitive training can improve state representation in young adults aged 18-30 diagnosed with psychotic illnesses, as well as those without psychiatric diagnoses. Participants will engage in either visual perception training or visual cognitive control training, with the option to complete all activities remotely. The research aims to address perceptual and cognitive deficits commonly observed in early psychosis, which can lead to significant functional impairments. By utilizing computationally-informed precision treatments, the study seeks to enhance cognitive control and working memory in affected individuals.
Who should consider this trial
Good fit: Ideal candidates include young adults aged 18-30 with a diagnosis of schizophrenia, schizoaffective disorder, or related psychotic disorders.
Not a fit: Patients with a history of severe substance use in the past three months may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cognitive functioning and quality of life for individuals with early psychosis.
How similar studies have performed: Other studies have shown promise in using cognitive training approaches for improving cognitive deficits in psychosis, indicating a potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA All Participants: 1. Between the ages of 18-30 at the time of screening 2. Fluent in spoken and written English, in that the participant learned to speak English before the age of 12 or is able to demonstrate fluency in conversation with study staff 3. Has an outpatient status and no hospitalization for psychiatric reasons for at least 1 month prior to participant 4. Has access to a computer with internet connection 5. Has a United States address as permanent residence Early Psychosis Participants: 6. Diagnosis of one of the following conditions (confirmed via interview): schizophrenia; schizoaffective disorder; schizophreniform disorder; Psychosis not otherwise specified (NOS); major depressive disorder with psychotic features; bipolar disorder with psychotic features 7. Willing to share contact with a clinical provider EXCLUSION CRITERIA All participants: 1. History of severe substance use in the past 3 months (determined by interview) 2. Unable to demonstrate capacity to consent to research, in the judgment of the study team 3. Diagnosed with a neurological disorder 4. Previous clinically significant head injury or prolonged unconsciousness 5. Significant cognitive training experience in the past 6 months 6. Meets criteria for clinical risk of suicidal behavior. Non-Psychosis participants: 7. Meets DSM-5 criteria for a psychotic, bipolar, or autism spectrum disorder 8. Has a family history (1st degree relative) of psychosis, bipolar, or autism spectrum disorders
Where this trial is running
Minneapolis, Minnesota
- University of Minnesota — Minneapolis, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Caroline Demro, PhD — University of Minnesota Department of Psychiatry and Behavioral Sciences
- Study coordinator: Rachel Roeske, BA
- Email: remstep@umn.edu
- Phone: 612-597-1415
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.