Cognitive-behavioral therapy for depression in adolescent girls at risk for type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of cognitive-behavioral therapy (CBT) on improving insulin sensitivity and reducing depressive symptoms in adolescent girls aged 12-17 who are at risk for type 2 diabetes. Participants will be divided into a CBT group and a health education control group, with assessments conducted over a one-year follow-up period. The study aims to evaluate changes in eating, physical activity, and sleep patterns as potential mediators of the intervention's effects. The focus is on racially and ethnically diverse girls with moderate depressive symptoms and a family history of type 2 diabetes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female
* Age 12-17 years
* Body mass index (BMI) ≥85th percentile for age \& sex
* Center for Epidemiologic Studies-Depression Scale (CES-D) \>20
* English speaking
* ≥1 first- or second-degree family member with type 2 diabetes (T2D), prediabetes, or gestational diabetes
* Good general health

Exclusion Criteria:

* Pregnancy or breastfeeding
* Type 2 diabetes as indicated by fasting glucose≥126 mg/dL or 2-hour glucose\>200 mg/dL or Hba1c\>=6.5
* Medication affecting mood, weight, cortisol, or insulin sensitivity, including insulin sensitizers (e.g., metformin), anti-depressants, and stimulants
* Major psychiatric disorder that, in the opinion of the investigators, would impede study compliance and necessitate more intensive treatment, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder, schizophrenia, conduct disorder, alcohol and substance abuse, and anorexia/bulimia nervosa
* Psychotherapy or structured weight loss program
* Active suicidal ideation or suicidal behavior

Where it's running

• Children's Hospital Colorado
  Aurora, Colorado, United States Recruiting

Study contacts

• Study coordinator: Lauren B Shomaker, PhD
• Email: lauren.shomaker@colostate.edu
• Phone: (970)491-3217

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.