Cognition and brain scans after a mini-stroke (TIA)
Cognitive Profile and Correlates in Neuroimaging After a Transient Ischemic Accident
This project will test whether changes on brain scans relate to thinking and memory problems in people over 60 who recently had a transient ischemic attack (TIA) compared with similar older adults with vascular risk factors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | University Hospital, Caen Academic / other |
| Locations | 1 site (Caen) |
| Trial ID | NCT04989608 on ClinicalTrials.gov |
What this trial studies
The study enrolls people aged 60 and over who had a focal neurological deficit lasting less than 24 hours with no ischemic lesion on diffusion MRI within one week, alongside age-matched controls from the Medit-AGEING cohort who have vascular risk factors. Participants undergo standardized neuroimaging and cognitive testing to look for subtle brain changes that might explain cognitive difficulties after TIA. Individuals with MRI contraindications or major neurological comorbidities are excluded. Imaging markers will be correlated with cognitive performance to explore possible mechanisms for post-TIA cognitive impairment at Caen University Hospital.
Who should consider this trial
Good fit: Ideal candidates are adults 60 years or older who recently had a TIA without diffusion-restricted injury on MRI and can undergo MRI and give informed consent, or age-matched controls with one or more cerebrovascular risk factors enrolled in Medit-AGEING.
Not a fit: Patients with contraindications to MRI, prior major neurological disease (such as stroke, dementia, brain tumor), or those unable to consent or under legal/administrative detention are unlikely to be eligible or benefit.
Why it matters
Potential benefit: If successful, the study could clarify why some people develop lasting thinking problems after a TIA and identify imaging markers to guide follow-up or future interventions.
How similar studies have performed: Previous work has reported cognitive changes after TIA and some subtle imaging abnormalities, but linking specific imaging toxicity signals to cognition in diffusion-negative TIA remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Transient ischemic accident Group * Patient over 60 years of age with a transient ischemic attack (focal neurological deficit of less than 24 hours without ischemic injury on diffusion MRI performed in the week following the event.) * Patient having signed a free and informed consent to participate in the Normandy-Stroke cohort. Control group * Subject over 60 years old * Subject included in the Medit-AGEING research protocol * Subject with one or more risk factor (s) for cerebrovascular disease * Subject not opposing the use of their data for the Cog-Tia study Non inclusion criteria Transient ischemic accident Group * Patient with contraindications to performing a brain MRI * Neurological co-morbidity (history of severe head trauma, dementia, brain tumor, stroke, psychosis) * Refusal to participate in the Normandy-Stroke cohort * Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric care, persons admitted to a health or social establishment for purposes other than that of research * Adult persons subject to a legal protection measure or unable to express their consent Control group \- Subject refusing to the use of their data for the Cog-Tia study Exclusion Criteria: * New stroke during the study participation
Where this trial is running
Caen
- Caen University Hospital — Caen, France (Recruiting)
Study contacts
- Study coordinator: Romain SCHNECKENBURGER, MD
- Email: schneckenburger-r@chu-caen.fr
- Phone: 0231065298
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.