Cognition and brain scans after a mini-stroke (TIA)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study enrolls people aged 60 and over who had a focal neurological deficit lasting less than 24 hours with no ischemic lesion on diffusion MRI within one week, alongside age-matched controls from the Medit-AGEING cohort who have vascular risk factors. Participants undergo standardized neuroimaging and cognitive testing to look for subtle brain changes that might explain cognitive difficulties after TIA. Individuals with MRI contraindications or major neurological comorbidities are excluded. Imaging markers will be correlated with cognitive performance to explore possible mechanisms for post-TIA cognitive impairment at Caen University Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Transient ischemic accident Group

* Patient over 60 years of age with a transient ischemic attack (focal neurological deficit of less than 24 hours without ischemic injury on diffusion MRI performed in the week following the event.)
* Patient having signed a free and informed consent to participate in the Normandy-Stroke cohort.

Control group

* Subject over 60 years old
* Subject included in the Medit-AGEING research protocol
* Subject with one or more risk factor (s) for cerebrovascular disease
* Subject not opposing the use of their data for the Cog-Tia study

Non inclusion criteria

Transient ischemic accident Group

* Patient with contraindications to performing a brain MRI
* Neurological co-morbidity (history of severe head trauma, dementia, brain tumor, stroke, psychosis)
* Refusal to participate in the Normandy-Stroke cohort
* Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric care, persons admitted to a health or social establishment for purposes other than that of research
* Adult persons subject to a legal protection measure or unable to express their consent

Control group

\- Subject refusing to the use of their data for the Cog-Tia study

Exclusion Criteria:

* New stroke during the study participation

Where it's running

• Caen University Hospital
  Caen, France Recruiting

Study contacts

• Study coordinator: Romain SCHNECKENBURGER, MD
• Email: schneckenburger-r@chu-caen.fr
• Phone: 0231065298

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.