How Therapeutic Failure Affects Living with Multiple Sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects patient-reported data from adults with RRMS to understand the psychosocial, economic, and quality-of-life impacts after therapeutic failure on disease-modifying therapy. Participants complete self‑report questionnaires about experiences, wellbeing, and socioeconomic factors. Data will help highlight unmet needs and inform patient-centered management strategies. The study includes adults on first-line or high‑efficacy DMTs for at least six months and excludes progressive MS and certain prior treatments. Recruitment is through multiple French academic hospital centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient aged 18 or over.
* Patient with RRMS according to McDonald 2024 criteria.
* Uninterrupted use of a moderately effective treatment, or highly effective treatment only if it is the first DMT, for at least 6 months.
* Collection of non-objection.
* Patient affiliated to the social security system.

Exclusion Criteria:

* Patient with progressive MS.
* Patient treated continuously with the same DMT for 3 years or more.
* Patient who received a second line DMT or an immunosuppressant before taking a first line DMT.
* Patients who have received mitoxantrone as the first treatment
* Pregnant or breast-feeding woman at the time of inclusion.
* Severe cognitive and/or psychological disorders which, according to the investigator (with or without a neuropsychological assessment), prevent the participant from completing the self-questionnaires independently and accurately.

Where it's running

• CHU de Caen Normandie
  Caen, France Recruiting
• CHU de Lille
  Lille, France Recruiting
• Groupement des Hôpitaux de l'Institut Catholique de Lille
  Lille, France Recruiting
• CHU de Rouen
  Rouen, France Recruiting

Study contacts

• Study coordinator: Pierre Branger, MD
• Email: branger-p@chu-caen.fr
• Phone: +33231064617

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.