Clinical Multimodal Surveillance of Respiratory Pathogens

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, nationwide observational effort to establish and refine a hospital-based surveillance and early warning system for respiratory pathogens. Data and biospecimens collected during routine care are transmitted every two weeks to monitor pathogen trends, support risk assessment, and inform prevention and control strategies. Eligible patients with respiratory syndrome seen in fever clinics, emergency departments, outpatient clinics, or inpatient wards across seven regions will contribute standardized clinical data and selected biospecimens for testing using routine pathogen panels, multiplex PCR, sequencing, and exploratory multi-omics analyses as clinically appropriate. The study aims to generate regional and national surveillance reports to aid early warning and public health responses. Interventions center on tiered pathogen testing and multi-omics analyses to enhance pathogen identification and characterization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with respiratory syndrome: Eligible patients are those diagnosed with respiratory syndrome based on the predefined data dictionary and the following ICD-10 (International Statistical Classification of Diseases, 10th Revision) diagnosis codes: R05, R50, J00, J01, J02, J03, J04, J06, J07, J08, J09, J10, J11, J12, J13, J14, J15, J16, J17, J18, J20, J21, J98.414, and J98.802.
* Patients with respiratory syndrome: Eligible patients are identified using the following search criteria. Patients meeting any one of the following criteria should be included:

  1. Medical history (History of Present Illness): Positive test result for a respiratory syndrome-related pathogen.
  2. Laboratory testing: Positive test result for a respiratory syndrome-related pathogen.
  3. Medication: Receipt of any of the following antiviral agents:

     Nirmatrelvir/Ritonavir Leritrelvir Xiannuotewei/Ritonavir Molnupiravir Azvudine Deuremidevir
  4. Diagnosis: Diagnosis containing the term "respiratory tract infection."

Exclusion Criteria:

* Participants who may compromise the study results: Patients who are unable to provide a specimen or whose specimen volume is insufficient for laboratory testing.
* Participants who are unable to comply with study procedures.

Where it's running

• Beijing You'an Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting
• The Fifth Affiliated Hospital of Guangzhou Medical University
  Guangzhou, Guangdong, China Recruiting
• The Fifth Affiliated Hospital of Sun Yat-sen University
  Zhuhai, Guangdong, China Recruiting
• The 980th Hospital of the People's Liberation Army Joint Logistics Support Force
  Shijiazhuang, Hebei, China Recruiting
• Heilongjiang Provincial Hospital
  Harbin, Heilongjiang, China Recruiting
• Jiamusi Central Hospital
  Jiamusi, Heilongjiang, China Recruiting

Study contacts

• Study coordinator: Jingwen Ai, M.D.
• Email: jingwenai@fudan.edu.cn
• Phone: +86 17317958269

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.