Chloride Imbalance in Very Preterm Infants
Official title: The Impact of Chloride Imbalance on BPD Development and Mortality in Preterm Infants
Run by Kanuni Sultan Suleyman Training and Research Hospital · NCT06940856 · Data updated 2026-11-12
This study looks to see if abnormal blood chloride in the first 4–6 weeks of life is linked to death or long-term lung problems in babies born very early.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Hour to 6 Weeks |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Kanuni Sultan Suleyman Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul, Turkey) |
| Status | Recruiting |
| Started | May 15, 2025 |
| Main results expected | April 15, 2027 |
| Study ends | December 15, 2027 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT06940856 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are infants born before 32 weeks gestation or weighing under 1500 g who were admitted to the NICU within 24 hours of birth.
✕Probably not a fit
Newborns with major congenital or chromosomal anomalies or those who had an enterostomy or were admitted after 24 hours may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study analyzes medical records from the past five years to examine whether low or high chloride levels in extremely preterm infants are associated with death or chronic lung issues. It focuses on infants born before 32 weeks gestation or weighing less than 1500 grams who were in the NICU within 24 hours of birth. The goal is to identify risk factors and conditions linked to dyschloremia in this population. The study builds on existing knowledge that dyschloremia relates to mortality and organ injury in other groups, and seeks to determine relevance in preterm infants. Results could inform monitoring and management of chloride balance in the NICU.
Why it matters
Potential benefit: If successful, it could improve risk stratification and guide closer monitoring of chloride balance to potentially reduce mortality and lung complications in very preterm infants.
How similar studies have gone: Prior research in older populations suggests dyschloremia is linked to worse outcomes, but data in very preterm infants are limited and this study addresses a gap.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infants born \<32 weeks PMA or \<1500 grams * Infants admitted to NICU within the first 24 hours Exclusion Criteria: * Infants with major congenital anomalies * Infants with chromosomal anomalies * Infants who have undergone enterostomy operation * Infants admitted to NICU after the first 24 hours
Where it's running
-
Kanuni Sultan Suleyman Education and Research Hospital
Istanbul, Turkey, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Murat Köstü
- Email: murat.kostu@saglik.gov.tr
- Phone: +905323932616
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.