Clinical trial Recruiting at 1 site Observational Ages 1 Hour to 6 Weeks

Chloride Imbalance in Very Preterm Infants

Official title: The Impact of Chloride Imbalance on BPD Development and Mortality in Preterm Infants

Run by Kanuni Sultan Suleyman Training and Research Hospital · NCT06940856 · Data updated 2026-11-12

This study looks to see if abnormal blood chloride in the first 4–6 weeks of life is linked to death or long-term lung problems in babies born very early.

Quick facts

Study typeObservational
Ages1 Hour to 6 Weeks
SexAll
Enrollment500 (estimated)
SponsorKanuni Sultan Suleyman Training and Research Hospital
Academic / other
Locations1 site (Istanbul, Turkey)
StatusRecruiting
StartedMay 15, 2025
Main results expectedApril 15, 2027
Study endsDecember 15, 2027
Registry record updatedAugust 6, 2026
Trial IDNCT06940856 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are infants born before 32 weeks gestation or weighing under 1500 g who were admitted to the NICU within 24 hours of birth.

Probably not a fit

Newborns with major congenital or chromosomal anomalies or those who had an enterostomy or were admitted after 24 hours may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes medical records from the past five years to examine whether low or high chloride levels in extremely preterm infants are associated with death or chronic lung issues. It focuses on infants born before 32 weeks gestation or weighing less than 1500 grams who were in the NICU within 24 hours of birth. The goal is to identify risk factors and conditions linked to dyschloremia in this population. The study builds on existing knowledge that dyschloremia relates to mortality and organ injury in other groups, and seeks to determine relevance in preterm infants. Results could inform monitoring and management of chloride balance in the NICU.

Why it matters

Potential benefit: If successful, it could improve risk stratification and guide closer monitoring of chloride balance to potentially reduce mortality and lung complications in very preterm infants.

How similar studies have gone: Prior research in older populations suggests dyschloremia is linked to worse outcomes, but data in very preterm infants are limited and this study addresses a gap.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Infants born \<32 weeks PMA or \<1500 grams
* Infants admitted to NICU within the first 24 hours

Exclusion Criteria:

* Infants with major congenital anomalies
* Infants with chromosomal anomalies
* Infants who have undergone enterostomy operation
* Infants admitted to NICU after the first 24 hours

Where it's running

  • Kanuni Sultan Suleyman Education and Research Hospital
    Istanbul, Turkey, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.