Characterizing lower-grade gliomas based on metabolic profiles
Official title: STRatifying Adult DIffuse Lower-grade Gliomas Based on Their VARIed Metabolic Profiles (STRADIVARI Project)
Run by I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · NCT06794736 · Data updated 2026-11-12
This study looks at the metabolic profiles of lower-grade gliomas to see how they affect treatment responses and survival in patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Academic / other |
| Locations | 4 sites (Bari, Apulia and 3 other locations) |
| Status | Recruiting |
| Started | November 14, 2024 |
| Main results expected | August 2026 |
| Study ends | August 2026 |
| Registry record updated | January 27, 2025 |
| Trial ID | NCT06794736 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a radiological diagnosis of lower-grade glioma and a complete clinical history.
✕Probably not a fit
Patients who are currently pregnant, lactating, or unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to better understand lower-grade gliomas by analyzing their molecular and metabolic characteristics. Participants will undergo routine treatment while their tumor samples are subjected to advanced metabolic analyses to identify distinct subgroups with varying behaviors and treatment responses. The study will correlate metabolic profiles with clinical outcomes such as progression-free survival and overall survival. Additionally, critical enzymes identified will be tested in a retrospective cohort to validate findings without requiring further patient intervention.
Why it matters
Potential benefit: If successful, this study could lead to more personalized treatment strategies for patients with lower-grade gliomas.
How similar studies have gone: Other studies have shown promise in using metabolic profiling for tumor characterization, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Prospective Metabolic Cohort: Inclusion Criteria: * Radiological diagnosis of brain tumor compatible with lower grade glioma * Full clinical history Exclusion Criteria: * Current pregnancy or lactation * Patients not able to provide informed consent Retrospective Cohort of FFPE samples: Inclusion Criteria: * Confirmed diagnosis of lower grade glioma * Full clinical and radiological history
Where it's running
-
IRCCS Galeazzi-Sant'Ambrogio
Milan, Lombardy, Italy Recruiting -
Ospedale San Paolo Bari
Bari, Apulia, Italy Not yet recruiting -
Policlinico Bari University Hospital (Bari, Italy)
Bari, Apulia, Italy Not yet recruiting -
Università Vita-Salute San Raffaele
Milan, Lombardy, Italy Active not recruiting
Study contacts
- Study coordinator: Lorenzo Bello, MD
- Email: direzionescientifica.ogsa@grupposandonato.it
- Phone: +390283502228
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.