Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Cerebellar TMS to Improve Thinking After Stroke

Official title: HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke

Run by Beijing Tiantan Hospital · NCT06316557 · Data updated 2026-11-12

This will test whether short courses of cerebellar intermittent theta burst stimulation (a type of rTMS) can improve thinking and memory in people who recently had an ischemic stroke and now have cognitive problems.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment70 (estimated)
SponsorBeijing Tiantan Hospital
Academic / other
Locations1 site (Beijing)
StatusRecruiting
StartedJanuary 1, 2025
Main results expectedJuly 1, 2026
Study endsApril 1, 2027
Registry record updatedJuly 2, 2025
Trial IDNCT06316557 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people with a recent ischemic stroke (within about two weeks) who have measurable cognitive impairment (MoCA < 26) and no history of seizures or brain hemorrhage.

Probably not a fit

People with hemorrhagic strokes, a history of epilepsy, no measurable cognitive impairment (MoCA ≥ 26), or who cannot travel for twice-daily sessions are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional trial compares active cerebellar intermittent theta burst stimulation (iTBS) to a sham procedure in people with cognitive impairment after recent ischemic stroke. Participants receive iTBS applied to the cerebellar hemisphere opposite the lesion twice daily for five days, while the control group receives sham stimulation with identical positioning and timing. Eligibility focuses on early ischemic stroke (initial event within about two weeks) and measurable cognitive impairment (MoCA < 26); key exclusions include hemorrhagic stroke and a history of epilepsy. Primary endpoints include change in cognitive measures and monitoring for adverse events to characterize safety and short-term efficacy.

Why it matters

Potential benefit: If successful, this could provide a short, noninvasive treatment to help speed recovery of thinking, memory, and daily function after ischemic stroke.

How similar studies have gone: Other small studies of rTMS for post-stroke cognitive or motor recovery have shown promising but preliminary results, and cerebellar iTBS specifically remains relatively novel with limited clinical data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Key inclusion criteria:

(1)ischemic stroke, with an initial incident occurring within 2 weeks;(2)MoCA\<26;

Key exclusion criteria:

(1)Cerebral hemorrhage or subarachnoid hemorrhage;(2)A pre-existing history of epilepsy;

Where it's running

  • Beijing Tiantan hospital
    Beijing, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • MSC Secretome Therapy for Cognitive Recovery After Subacute Ischemic Stroke

    This pilot trial tests whether adding mesenchymal stem cell secretome to standard stroke care helps improve cognitive recovery in adults 40–75 with subacute ischemic stroke and mild-to-moderate cognitive impairment.

    Recruiting Hasanuddin University · Makassar, South Sulawesi · NCT07731087

  • AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

    This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

    Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

  • Remote ischemic conditioning for post-stroke insomnia

    A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.

    Recruiting Sichuan Academy of Medical Sciences · Chengdu, Sichuan · NCT07874594

  • Ear-based nerve stimulation to help sleep after a stroke

    A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.

    Recruiting Casa Colina Hospital and Centers for Healthcare · Pomona, California · NCT07858656

  • Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)

    This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.

    Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle · NCT07834333

  • Preventing another ischemic stroke with a smart bracelet and app

    This study tests whether a digital prevention program using a wearable and a mobile app can help people who recently had an ischemic stroke reduce the chance of another stroke and improve risk-factor control.

    Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07825311

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.