Cerebellar TMS to Improve Thinking After Stroke
Official title: HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke
Run by Beijing Tiantan Hospital · NCT06316557 · Data updated 2026-11-12
This will test whether short courses of cerebellar intermittent theta burst stimulation (a type of rTMS) can improve thinking and memory in people who recently had an ischemic stroke and now have cognitive problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | July 1, 2026 |
| Study ends | April 1, 2027 |
| Registry record updated | July 2, 2025 |
| Trial ID | NCT06316557 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with a recent ischemic stroke (within about two weeks) who have measurable cognitive impairment (MoCA < 26) and no history of seizures or brain hemorrhage.
✕Probably not a fit
People with hemorrhagic strokes, a history of epilepsy, no measurable cognitive impairment (MoCA ≥ 26), or who cannot travel for twice-daily sessions are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional trial compares active cerebellar intermittent theta burst stimulation (iTBS) to a sham procedure in people with cognitive impairment after recent ischemic stroke. Participants receive iTBS applied to the cerebellar hemisphere opposite the lesion twice daily for five days, while the control group receives sham stimulation with identical positioning and timing. Eligibility focuses on early ischemic stroke (initial event within about two weeks) and measurable cognitive impairment (MoCA < 26); key exclusions include hemorrhagic stroke and a history of epilepsy. Primary endpoints include change in cognitive measures and monitoring for adverse events to characterize safety and short-term efficacy.
Why it matters
Potential benefit: If successful, this could provide a short, noninvasive treatment to help speed recovery of thinking, memory, and daily function after ischemic stroke.
How similar studies have gone: Other small studies of rTMS for post-stroke cognitive or motor recovery have shown promising but preliminary results, and cerebellar iTBS specifically remains relatively novel with limited clinical data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Key inclusion criteria: (1)ischemic stroke, with an initial incident occurring within 2 weeks;(2)MoCA\<26; Key exclusion criteria: (1)Cerebral hemorrhage or subarachnoid hemorrhage;(2)A pre-existing history of epilepsy;
Where it's running
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Beijing Tiantan hospital
Beijing, China Recruiting
Study contacts
- Principal investigator: Zixiao LI, Dr. — Beijing Tiantan Hospital
- Study coordinator: Weili Jia, Dr.
- Email: jiawl1994@163.com
- Phone: +86 13120207987
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.