Cannabis-derived THC vs CBD in people with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2, randomized, double-blind trial comparing THC and CBD taken orally for 15 weeks in adults with multiple sclerosis and neurogenic bladder symptoms. Participants complete cognitive tests and questionnaires to see how each cannabinoid affects cognitive function and bladder-related symptoms. The trial aims to clarify potential cognitive risks and differences between THC and CBD in this population. Eligibility includes adults 26-59 with MS and NLUTD, stable NLUTD treatment, and consent to participate; exclusions cover major psychiatric or neurological conditions and recent cannabis use. The study is led by the University of Calgary with partner support from the MS Society of Canada, at Calgary sites.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 26 and 59 years inclusive.
* Confirmed diagnosis of Multiple Sclerosis as per McDonald criteria (any type) \[12\]
* Symptoms of neurogenic lower urinary tract dysfunction (NLUTD) as measured by neurogenic bladder symptom score (NBSS), with a minimum score of 7.
* If already on a medication for NLUTD, must be stable on this medication for at least 4 weeks.
* Sexually active men and women of child-bearing potential must agree to use adequate contraception.
* Written informed consent.

Exclusion Criteria:

* Major psychiatric disorder such as schizophrenia or bipolar disorder
* Major neurological disorder which could affect cognition such as dementia, traumatic brain injury.
* Seizure disorder
* Use of antipsychotic medication
* Use of benzodiazepines other than exclusively at night/bedtime
* Experienced a MS relapse in the last ninety (90) days.
* Current use of cannabis or CBM greater than 3x/week.
* Currently using cannabis/CBM less than 3x/week and being unwilling to abstain for the duration of the study.
* Visual acuity (binocular) worse than 20/70 (in order to complete the cognitive outcomes)
* Significant upper extremity disability that would interfere with the cognitive tests battery.
* Indwelling catheter use/urinary diversion
* Pregnant or Breastfeeding

Where it's running

• University of Calgary Foothills Medical Center
  Calgary, Alberta, Canada Recruiting
• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Study coordinator: Sarah A Morrow, MD, MS, FRCPC, FAAN
• Email: sarah.morrow@albertahealthservices.ca
• Phone: 1-403-9444241

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.