Cangrelor's effects on heart function during heart procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of Cangrelor, an intravenous antiplatelet medication, on coronary microvascular dysfunction in patients with chronic coronary syndromes undergoing elective percutaneous coronary interventions (PCI). It compares the efficacy of Cangrelor to standard treatment with Clopidogrel in preventing microvascular damage during these procedures. Patients will be monitored for changes in coronary flow reserve and index of microcirculatory resistance before and after PCI. The goal is to determine if Cangrelor can provide better protection for the heart's microcirculation during these interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients;
* Signed Informed Consent;
* Chronic coronary syndromes;
* P2Y12-inhibitors naive patients;
* Elective PCI of a functionally significant (FFR ≤ 0.80) de-novo intermediate coronary artery stenoses in a major vessel;

Exclusion Criteria:

* Underaged patients;
* Acute Conorary Syndromes;
* Already on treatment with P2Y12-inhibitors;
* Heart failure with severe reduction of the left ventricle ejection fraction (LVEF \< 30%);
* Subtotal occlusion (diameter stenosis \> 90%) of the target lesion;

Where it's running

• Division of Cardiology - Federico II University Hospital
  Naples, Italy Recruiting
• Division of Cardiology, University Hospital of Ferrara
  Ferrara, Italy Not yet recruiting

Study contacts

• Study coordinator: Luigi Di Serafino, MD, PhD
• Email: luigi.diserafino@unina.it
• Phone: +390817462235

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.