Can short-term atorvastatin around surgery help prevent atrial fibrillation after lung surgery?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, phase 4 trial compares short-term atorvastatin to a matching placebo in adults 60 and older undergoing isolated lung resection. Participants are assigned to receive atorvastatin or placebo around the time of surgery to see if it lowers the rate of atrial fibrillation or related rapid heart rhythms within 72 hours post-surgery. The study also monitors safety by tracking liver, kidney, and muscle-related laboratory changes during treatment. Standard postoperative care is provided to all participants, with outcomes assessed through rhythm monitoring and lab tests. The trial is conducted at Peking Union Medical College Hospital in Beijing, with everyone following the same protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 60 years or older.
* Scheduled to undergo isolated anatomical lung resection, including pulmonary segmentectomy or lobectomy.
* Sinus rhythm documented by a preoperative electrocardiogram.
* Not receiving antiarrhythmic medication, with the exception of beta-blockers.
* Willing and able to provide written informed consent.

Exclusion Criteria:

* Untreated hyperthyroidism or hypothyroidism.
* History of obstructive hepatobiliary disease, active liver disease, or other serious liver disease.
* Preoperative serum creatinine greater than 150 μmol/L.
* Known allergy to atorvastatin or another statin, or a history of a serious statin-related adverse reaction, including statin-associated myopathy.
* Personal or family history of an inherited muscle disorder.
* Continuous use within 1 month before randomization of fibrates, niacin, or medications that strongly inhibit cytochrome P450 or P-glycoprotein, including cyclosporine, oral azole antifungal agents, certain interacting antibiotics, protease inhibitors, nefazodone, or amiodarone.
* Consumption of 1 liter or more of grapefruit juice per day within 1 month before randomization.
* Current treatment with a high-intensity statin regimen, including atorvastatin 40 mg/day or higher or rosuvastatin 20 mg/day or higher.
* Any other condition that, in the investigator's judgment, would make participation unsafe or interfere with the conduct or evaluation of the study.

Where it's running

• Peking Union Medical College Hospital
  Beijing, China Recruiting
• Peking Union Medical College Hospital
  Beijing, China Not yet recruiting

Study contacts

• Study coordinator: Tao Lu, MD,PhD
• Email: lutaowhiz@sina.com
• Phone: 01069152630

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.