Can intrauterine insemination help next pregnancies after unexplained pregnancy loss?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, open-label randomized trial compares IUI to natural conception in couples with a recent unexplained pregnancy loss. About 706 couples will be enrolled and randomly assigned to receive IUI or attempt natural conception, then followed to assess subsequent pregnancy outcomes. The trial aims to provide high-quality evidence on whether IUI improves reproductive outcomes in this population. It is led by Lanzhou University Second Hospital and includes sites in Beijing, Lanzhou, and Shijiazhuang. Results could influence clinical practice for managing unexplained pregnancy loss.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants aged 20-37 years.
* History of at least one ultrasound-confirmed pregnancy loss (excluding biochemical pregnancy, ectopic pregnancy, and hydatidiform mole), with the most recent pregnancy loss occurring within the previous 12 months.
* Desire for pregnancy at the time of enrollment.
* Basal follicle-stimulating hormone (FSH) \<10 IU/L.
* Anti-Müllerian hormone (AMH) \>1.1 ng/mL.
* Male partner's semen analysis meeting the criteria for intrauterine insemination (IUI), with a post-processing total progressive motile sperm count ≥5 × 10⁶.
* Ability and willingness to provide written informed consent.

Exclusion Criteria:

* Congenital or acquired uterine structural abnormalities.
* Thyroid dysfunction, defined as thyroid-stimulating hormone (TSH) \>4.0 mIU/L.
* Positive antiphospholipid antibodies, including lupus anticoagulant, anticardiolipin antibodies, or anti-β2 glycoprotein I antibodies.
* Parental chromosomal abnormalities or a history of fetal chromosomal abnormalities in a previous pregnancy.
* Participation in another interventional clinical trial during the study period.

Where it's running

• Lanzhou university second hosipital
  Lanzhou, Gansu, China Recruiting
• Beijing Amcare Beisanhuan Women's & Children's Hospital
  Beijing, Beijing Municipality, China Not yet recruiting
• Hebei Reproductive Health Hospital
  Shijiazhuang, Hebei, China Not yet recruiting

Study contacts

• Study coordinator: Fang Wang, PhD
• Email: ery_fwang@lzu.edu.cn
• Phone: +86 13919302888

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Fast- vs slow-absorbing sutures in ultra tension-reducing closure

  This study tests whether slow-absorbing sutures lead to better scar outcomes than fast-absorbing sutures in a single patient at a time after a linear surgical incision.

  Recruiting Lanzhou University Second Hospital · Lanzhou, Gansu · NCT07639372

• Irrigation Fluid Absorption and Perioperative cfDNA Changes in TURBT for Bladder Cancer

  This study tests whether the amount of irrigation fluid absorbed during TURBT is linked to changes in tumor DNA circulating in the blood in patients with bladder cancer.

  Recruiting Lanzhou University Second Hospital · Lanzhou, Gansu · NCT07589413

• Negative-pressure suction during flexible ureteroscopy to reduce fluid absorption and infections

  This test will see if using a negative-pressure suction sheath during retrograde intrarenal surgery for adults with kidney stones reduces how much irrigation fluid their bodies absorb and lowers the risk of postoperative infections.

  Recruiting Lanzhou University Second Hospital · Lanzhou, Gansu · NCT07492147

• Doxycycline with or without progestin for chronic endometritis in women with recurrent reproductive failure

  This trial tests whether adding the progestin medroxyprogesterone acetate to doxycycline improves pregnancy outcomes for women with chronic endometritis and recurrent reproductive failure.

  Recruiting Lanzhou University Second Hospital · Lanzhou, Gansu · NCT07488949

• Mass spectrometry test to detect multiple gene mutations in bladder cancer

  This project will try a nucleic-acid mass spectrometry test on tumor and matched normal tissue to detect many clinically relevant gene mutations in adults with bladder cancer.

  Recruiting Lanzhou University Second Hospital · Lanzhou, Gansu · NCT07424560

• Enhanced recovery after laparoscopic distal gastrectomy without routine abdominal drainage tubes

  This trial will test whether skipping routine abdominal drainage tubes during enhanced recovery after laparoscopic distal gastrectomy helps adults (18–80) with gastric adenocarcinoma recover as well as using drains.

  Recruiting at 6 sites Phase 3 Lanzhou University Second Hospital · Beijing, Beijing Municipality and 5 other locations · NCT07029269

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.