Doxycycline with or without progestin for chronic endometritis in women with recurrent reproductive failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial assigns women aged 20–45 with CD138-confirmed chronic endometritis and recurrent reproductive failure to receive either doxycycline plus medroxyprogesterone acetate or doxycycline plus placebo. Participants must be planning to conceive within 12 months and will undergo hysteroscopy and endometrial biopsy at baseline. The study follows participants for reproductive outcomes including pregnancy, ongoing pregnancy, spontaneous miscarriage, and live birth. Safety and tolerability of the treatment regimens will also be monitored.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* women aged 20-45 years;
* plans to conceive within 12 months;
* chronic endometritis(CE) confirmed by endometrial CD138 immunohistochemistry (IHC);
* a diagnosis of recurrent reproductive failure(RRF);
* willingness to undergo hysteroscopy and endometrial biopsy;
* no contraindications to the study medications.

Exclusion Criteria:

* acute genital tract infection, gynecologic malignancy, endometrial hyperplasia, or uterine fibroids;
* pregnancy or lactation;
* contraindications to hysteroscopy or anesthesia;
* use of antibiotics, glucocorticoids, estrogens, or progestins within 3 months before trial initiation;
* allergy to doxycycline or medroxyprogesterone acetate(MPA);
* abnormal semen parameters in the male partner.

Where it's running

• Lanzhou University Second Hospital
  Lanzhou, Gansu, China Recruiting

Study contacts

• Principal investigator: Fang Wang — Lanzhou University Second Hospital
• Study coordinator: Fang Wang
• Email: ery_fwang@lzu.edu.cn
• Phone: 13919302888

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Berberine plus doxycycline versus doxycycline alone for chronic endometritis

  This trial tests whether adding berberine to standard doxycycline helps women of childbearing age with chronic endometritis diagnosed by CD138 to become cured more often.

  Recruiting Phase 1/2 The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT07180563

• Fertility outcomes after antibiotic treatment in women with chronic endometritis

  This study tests whether antibiotic therapy can improve fertility and pregnancy outcomes in women with chronic endometritis diagnosed during infertility workups.

  Recruiting at 2 sites Faculty Hospital Kralovske Vinohrady · Prague and 1 other locations · NCT07603492

• The FLORA project: looking for endometrium microbes linked to chronic endometritis and pregnancy success

  This study tests the relationship between the endometrial microbiome and chronic endometritis in women undergoing IVF/ICSI.

  Recruiting Universitair Ziekenhuis Brussel · Brussels · NCT05337072

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.