Brain MRI connectivity after cardiac arrest using mobile and high-field scanners

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares high-field MRI (1.5–3 Tesla) with very low-field, mobile MRI to generate brain connectivity maps in adults who are comatose after cardiac arrest and in healthy volunteers. It aims to determine whether these imaging approaches can improve neuroprognostication by revealing patterns of white and gray matter injury. The study uses multimodal MRI acquisitions to assess structural networks and identify differences between comatose patients and controls. Conducted under safety and feasibility constraints, it addresses logistical barriers of HF-MRI in critically ill patients by evaluating a bedside VLF-MRI option. Outcomes will inform whether integrating these imaging modalities could reduce inappropriate WLST and guide care decisions.

Why it matters

Who can join: the full rules

Inclusion criteria :

COMA PATIENTS

* Adult patients (male or female ≥ 18 years).
* Coma, as indicated by a Glasgow Coma Scale (GCS) ≤ 8 (motor score ≤ 2) immediately after CA resuscitation and before sedation onset.
* Written informed consent from patient's legal representative.
* Affiliation to the French social security system

HEALTHY VOLUNTEERS

* Adult patients (male or female ≥ 18 years).
* Written informed consent.
* Affiliation to the French social security system

Exclusion criteria :

COMA PATIENTS

* Brain death.
* Coma explained by other cause than CA.
* Pregnancy.
* MRI contraindication: medical material not MRI compatible.
* Hemodynamic instability or respiratory failure precluding patient's transport and MRI scanning.

HEALTHY VOLUNTEERS

* Pregnancy.
* MRI contraindication: medical material not MRI compatible.
* Volunteers who do not wish to be informed of an abnormality detected on MRI a posteriori

Where it's running

• CHU de Toulouse
  Toulouse, France Recruiting

Study contacts

• Study coordinator: Stein SILVA
• Email: silva.s@chu-toulouse.fr
• Phone: (+33)5 61 77 97 28

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.