Boosting Smell Training in Adults with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 trial compares conventional at-home olfactory training with a scented marker training approach over 8 weeks in adults living with HIV. Participants are randomized to one of the two interventions after a baseline assessment, then return for a post-intervention evaluation of olfactory and cognitive performance. The study uses a two-group pre-post design and stratified randomization by gender and smoking status to control for potential confounders. Recruitment is from the UAB 1917 HIV/AIDS Clinic, with in-person baseline and posttest visits and customary follow-up procedures. The primary goals are to assess feasibility and acceptability as well as any improvements in olfactory and cognitive function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants (men \& women) must be 40+ years
* have cognitive complaints.
* must be proficient in English

Exclusion Criteria:

* a sinus infection (within the past 3 months), thrush, candidiasis, pregnant, current cold or flu, hay fever, asthma, nasal allergies, opportunistic infections (including COVID-19) within the past 3 months, or current nasal obstruction condition.
* Participation requires \~8 weeks and in-person visits, participants living beyond 60 miles away from the center will be excluded.
* Participants living in unstable housing (e.g., shelter) or with significant neuro-comorbidities (e.g., schizophrenia) will be excluded.
* Other conditions (e.g., legally blind/deaf, currently undergoing radiation or chemotherapy, or a history of significant brain trauma) that could impact olfactory and cognitive testing also necessitate exclusion.

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Study coordinator: David E Vance, PhD
• Email: devance@uab.edu
• Phone: 1205-934-7589

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.