Clinical trial Recruiting at 1 site Interventional Ages 16 and up Men only

TransAction program to improve HIV prevention and care for transgender women in Ho Chi Minh City

Official title: Adaptation and Implementation of an Evidence-based Approach to Advance HIV Prevention and Care

Run by University of California, Los Angeles · NCT07495059 · Data updated 2026-11-12

This trial will test whether TransAction—individual risk-reduction sessions, skill-building and group support, plus social events—helps transgender women in Ho Chi Minh City move forward in HIV prevention and care compared with social events alone.

More HIV (Human Immunodeficiency Virus) trials

Quick facts

Study typeInterventional
Ages16 Years and up
SexMen only
Enrollment80 (estimated)
SponsorUniversity of California, Los Angeles
Academic / other
Locations1 site (Ho Chi Minh City)
StatusRecruiting
StartedMarch 1, 2026
Main results expectedOctober 1, 2026
Study endsJanuary 10, 2027
Registry record updatedApril 21, 2026
Trial IDNCT07495059 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are transgender women (male at birth, currently self-identified as transgender women) aged 16 or older who live in or near Ho Chi Minh City, have no plans to move in the next six months, and can give informed consent.

Probably not a fit

People unlikely to benefit include those who are not transgender women, who do not live in the Ho Chi Minh City area or cannot attend in-person sessions, who previously participated in adaptation activities with the team, or who are unable to provide informed consent.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Eighty transgender women will be randomly assigned to receive the full TransAction package (individual risk-reduction sessions, skill-building and open group support sessions, and social events) or to a control condition invited to social events only. Outcomes including movement along the HIV prevention and care continua, sexual risk behavior, substance use, self-efficacy in seeking services, social support, stigma, well-being, and quality of life will be measured at baseline, 3 months, and 6 months. The study will also document implementation outcomes such as fidelity, adaptation, feasibility, acceptability, and sustainability using implementation records, investigator evaluation, and surveys and focus groups with peer facilitators and participants. The trial is led by UCLA in collaboration with local and international partners and is conducted at the University of Medicine and Pharmacy in Ho Chi Minh City.

Why it matters

Potential benefit: If successful, TransAction could increase engagement in HIV prevention and care, reduce risk behaviors, and improve social support and quality of life for transgender women in the area.

How similar studies have gone: Peer-led, skills-building and social support interventions for transgender women and other key populations have shown promise in improving prevention and care engagement, but adaptation and implementation evidence specifically in Vietnam is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 16 years of age or older
* being male at birth and currently self-identified as a TW
* currently living in Ho Chi Minh City adjacent areas and having no plans to move out of the areas in the next 6 months - have the cognitive capacity to participate in study activities as judged by the study recruiter.

Exclusion Criteria:

* have been involved in intervention adaptation activities previously with the study team
* inability to give informed consent/assent

Where it's running

  • University of Medicine and Pharmacy
    Ho Chi Minh City, Vietnam
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.