Bone Myoregulation and Posture in Vitamin D Deficiency

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center observational study compares adults with vitamin D deficiency to healthy controls to explore how vitamin D status relates to balance and reflex muscle activity. Participants undergo a one-time session with surface electromyography and postural stability tests under varying loading and vibration conditions. No invasive procedures or blood draws are performed; vitamin D status is determined from routine prior test results. Data will be analyzed to identify differences in neuromuscular responses and postural control between groups, aiming to inform future rehabilitation approaches. The study is designed to deepen understanding of neuromuscular adaptations associated with vitamin D deficiency.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 20 to 40 years.
* Ability to provide written informed consent.
* Vitamin D deficiency group: serum 25-hydroxyvitamin D level \<10 ng/mL measured within the last 3 months (routine clinical testing).
* Healthy control group: normal vitamin D status based on routine clinical testing within the last 3 months.
* No use of vitamin D or calcium supplementation within the last 3 months.

Exclusion Criteria:

* Known metabolic bone disease other than vitamin D deficiency.
* Neurological disorder (central or peripheral) or neuromuscular disease.
* History of lower-limb surgery, fracture, or prosthesis affecting standing balance.
* Vestibular disorder.
* BMI \>30 kg/m2.
* Active malignancy.
* Severe psychiatric disorder.
* Skin condition preventing placement of surface EMG electrodes.

Where it's running

• Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Selim Sezikli, MD — Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
• Study coordinator: Selim Sezikli, MD
• Email: selimsezikli@hotmail.com
• Phone: +905065101833

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.