Adding exercise to vitamin D treatment for diabetic men with erectile dysfunction and low vitamin D.
Official title: Is There a Benefit From Addition of Exercise in Diabetic Patients With ED Who Complain Low Vitamin D?
Run by Cairo University · NCT07366970 · Data updated 2026-11-12
This trial will see if adding regular moderate treadmill walking to high‑dose vitamin D replacement helps men with type 2 diabetes, chronic erectile dysfunction, and low vitamin D levels.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 35 Years to 45 Years |
| Sex | Men only |
| Enrollment | 40 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Dokki, Giza Governorate) |
| Status | Recruiting |
| Started | December 5, 2025 |
| Main results expected | May 5, 2026 |
| Study ends | May 5, 2026 |
| Registry record updated | January 26, 2026 |
| Trial ID | NCT07366970 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are men with type 2 diabetes who have chronic erectile dysfunction for more than 24 months, documented low vitamin D, and who can safely perform moderate exercise without major cardiopulmonary, renal, or liver disease.
✕Probably not a fit
Patients with severe heart, lung, kidney, or liver disease, those whose ED is due to non‑modifiable structural or neurological causes, or those unable to exercise are less likely to benefit from the exercise component.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Forty men with type 2 diabetes, chronic erectile dysfunction (>24 months), and documented vitamin D deficiency will be divided into two groups. Both groups will receive cholecalciferol 200,000 IU every two weeks for 12 weeks, while one group will also do supervised treadmill walking for one hour at moderate intensity three times per week for 12 weeks. Participants with cardiac, respiratory, renal, or liver disease are excluded. The study will track changes in erectile function and vitamin D status over the 12‑week period to compare the added effect of exercise versus vitamin D alone.
Why it matters
Potential benefit: If successful, adding regular moderate exercise to vitamin D replacement could improve erectile function and overall health beyond vitamin D alone.
How similar studies have gone: Previous studies show exercise and vitamin D supplementation can each improve metabolic health and some risk factors for sexual dysfunction, but combining supervised exercise with high‑dose vitamin D in diabetic ED is not well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diabetic men (forty) * type 2 diabetes * complaint of erectile dysfucntion (chronic complaint more than 24 months) * men with low vitamin D (deiciency in vitamin D) Exclusion Criteria: * cardiac patients * respiratory disease patients * renal disease * liver disease
Where it's running
-
Cairo University
Dokki, Giza Governorate, Egypt Recruiting
Study contacts
- Principal investigator: Ali MA Ismail, lecturer — Cairo University
- Study coordinator: Ali MA Ismail, lecturer
- Email: ali.mohamed@pt.cu.edu.eg
- Phone: 01005154209
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Vitamin D Supplementation in Children with Irritable Bowel Syndrome
This study tests whether giving vitamin D to children with IBS and low vitamin D levels can improve their IBS symptoms compared with a placebo.
-
HIP2602 for Erectile Dysfunction: Testing a new treatment in adults
This study tests whether HIP2602, alone or with related formulations, can improve erectile function in adult men with long-standing erectile dysfunction who partner with the same adult female partner.
-
Preventing lower limb artery disease in adults with diabetes using a risk-prediction model and HAPA-based nursing
A risk-prediction model is tested in adults with type 2 diabetes to see if a nursing plan based on the HAPA model can reduce peripheral artery disease in the legs.
-
Platelet-Rich Plasma for Erectile Dysfunction After Prostate Surgery
This trial tests whether injecting a patient’s own platelet-rich plasma can improve erectile function in men who have persistent ED more than a year after nerve-sparing radical prostatectomy.
-
Pudendal artery plaque and erectile dysfunction in men with heart disease
A small study tests whether plaque in the internal pudendal arteries is linked to erectile function in men with coronary artery disease who are undergoing coronary angiography.
-
Piezoelectric Low-Intensity Shockwave Therapy for erectile dysfunction in PDE5i nonresponders
This study tests whether four weeks of low‑intensity, linear piezoelectric shockwave therapy can improve erectile function in men with ED who did not respond to PDE5 inhibitors.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.