BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, pragmatic randomized trial enrolls adults undergoing elective pulmonary resection with one-lung ventilation under general anesthesia. Participants are assigned to either a fixed PEEP of 4 cmH2O or BMI-adjusted PEEP, to see which approach best supports oxygenation and lung mechanics during OLV. The study uses a simple, pre-procedure BMI measure to tailor PEEP without complex titration. It is open-label and aims to reflect real-world practice across several Spanish centers. Enrollment targets 150 participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18 years or older.
2. Scheduled thoracic surgery for pulmonary resection requiring general anesthesia and one-lung ventilation.
3. Written informed consent obtained before any study-specific procedure.

Exclusion Criteria:

1. Simultaneous participation in another interventional clinical trial that could interfere with the protocol.
2. Severe hemodynamic instability before the start of the procedure, defined as continuous vasopressor infusion or shock of any etiology.
3. Severe restrictive lung disease, defined as total lung capacity \<50% of predicted or forced vital capacity \<50% of predicted.
4. Body mass index \>45 kg/m2.

Where it's running

• Hospital Universitario de La Princesa
  Madrid, Madrid, Spain Recruiting
• Hospital Clinic Barcelona
  Barcelona, Catalonia, Spain Not yet recruiting
• Hospital de la Santa Creu i Sant Pau
  Barcelona, Catalonia, Spain Not yet recruiting
• Hospital General Universitario Geogorio Marañón
  Madrid, Madrid, Spain Not yet recruiting

Study contacts

• Study coordinator: Jesús M Nieves Alonso, MD
• Email: jesusmna@gmail.com
• Phone: +34915202540

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hyperangulated vs standard videolaryngoscopy vs direct laryngoscopy for double-lumen tube intubation

  This trial tests three laryngoscopy methods to place a double-lumen tube in adults having thoracic surgery with one-lung ventilation.

  Recruiting Trakya University · Edirne, Edirne · NCT07614529

• Auditory and touch stimulation to help people wake after general anesthesia

  This trial will try verbal cues plus shoulder tapping or shaking during emergence to see if adults having laparoscopic abdominal surgery wake faster and more smoothly from general anesthesia.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07339618

• Respiratory acidosis during one-lung ventilation and how clinician settings compare with the VentilO app

  This project will try to see if ventilator settings chosen by clinicians or settings suggested by the VentilO smartphone app better prevent respiratory acidosis in adults having one-lung ventilation for thoracic surgery.

  Recruiting Laval University · Québec, Quebec · NCT07099963

• Comparing bronchial blockers and double-lumen tubes in esophagectomy

  This study is testing if using a bronchial blocker instead of a double-lumen tube during esophagus surgery can help prevent voice problems in adults who need lymph node removal near their vocal cords.

  Recruiting Samsung Medical Center · Seoul · NCT06897501

• Examining EEG changes in children under general anesthesia

  This study is trying to see how different types of anesthesia affect brain activity in children during surgery to make anesthesia safer and more effective.

  Recruiting Peking University First Hospital · Beijing · NCT05210764

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.