Examining EEG changes in children under general anesthesia
General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
Peking University First Hospital · NCT05210764
This study is trying to see how different types of anesthesia affect brain activity in children during surgery to make anesthesia safer and more effective.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 366 (estimated) |
| Ages | 1 Minute to 18 Years |
| Sex | All |
| Sponsor | Peking University First Hospital (other) |
| Locations | 1 site (Beijing) |
| Trial ID | NCT05210764 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how different general anesthetics affect the electroencephalogram (EEG) patterns in children during surgery. It aims to analyze specific indices derived from processed EEG (pEEG), such as phase-amplitude coupling and bicoherence, to determine their ability to predict anesthesia depth. The study addresses the limitations of current anesthesia depth monitoring methods in pediatric patients, which can lead to risks during surgery. By exploring these EEG changes, the research seeks to improve the safety and effectiveness of anesthesia in children.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 0-18 years scheduled for elective surgery and classified as American Society of Anesthesiologists Physical Status I-II.
Not a fit: Patients who may not benefit from this study include those with preterm birth, significant medical conditions, or allergies to the anesthetics being studied.
Why it matters
Potential benefit: If successful, this study could enhance the monitoring of anesthesia depth in pediatric patients, reducing the risks associated with improper anesthesia levels.
How similar studies have performed: While the specific approach of analyzing pEEG indices in children under general anesthesia is novel, similar studies have shown the potential of EEG monitoring in anesthesia depth assessment.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients aged 0-18 years, American Society of Anesthesiologists Physical Status I-II, scheduled for elective surgery in Peking University First Hospital. Exclusion Criteria: * Preterm patients; * Height and weight not within the standard ranges for respective ages; * Surgery for head or heart; * Patients with muscular, neurologic or psychiatric diseases; * Patients with Congenital anomaly or hereditary diseases; * Patients with medication abuse; * Allergy to medication including propofol, sevoflurane, and ketamine; * Allergy to beans; * Refusal to participate the study by guardians.
Where this trial is running
Beijing
- Peking University First Hospital — Beijing, China (RECRUITING)
Study contacts
- Study coordinator: Linlin Song, MD
- Email: songlinlinlynkia@163.com
- Phone: 86-13501309217
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: General Anesthetic, Electroencephalogram, general anesthetic, electroencephalogram