Blood test using circular RNAs for early detection of colorectal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project collects pre-treatment plasma from adults with histologically confirmed stage I–III colorectal cancer at City of Hope to profile cell-free circular RNAs (cf-circRNAs). Researchers will isolate cf-circRNAs from plasma and quantify them using RT-qPCR and next-generation sequencing to identify tumor-associated signatures. The team aims to develop a minimally invasive liquid biopsy assay that could complement colonoscopy and stool-based tests. Diagnostic performance will be compared to clinical and pathological tumor data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years old)
* Histologically confirmed colorectal cancer (Stage I-III)
* Availability of pre-treatment plasma samples
* Written informed consent provided

Exclusion Criteria:

* History of other active malignancies within the past 5 years
* Poor sample quality or hemolysis
* Inability to provide informed consent

Where it's running

• City of Hope Medical Center
  Duarte, California, United States Recruiting

Study contacts

• Principal investigator: Ajay Goel, PhD — City of Hope Medical Center
• Study coordinator: Goel Ajay, PhD
• Email: ajgoel@coh.org
• Phone: 626-218-3452

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.