Blood cell mitochondrial function and oxidative stress in pre-capillary pulmonary hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, non-interventional study enrolling 120 adults with right-heart-catheterization–confirmed pre-capillary pulmonary hypertension who will be followed for three years. Blood samples (PBMCs and platelets) will be collected up to three times per year during routine visits to measure mitochondrial respiration and markers of oxidative stress. Those blood measures will be compared with standard clinical and cardiac function data such as echocardiography, right heart catheterization, six-minute walk tests, and functional status. The goal is to determine whether circulating blood-cell signatures track disease severity or progression and could inform more personalized monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years) diagnosed with pre-capillary pulmonary hypertension confirmed by right heart catheterization
* Patients classified according to the international clinical classification:

  * Group 1: Pulmonary arterial hypertension (PAH)
  * Group 3: Pulmonary hypertension associated with chronic respiratory diseases and/or hypoxia
  * Group 4: Chronic thromboembolic pulmonary hypertension (CTEPH)
* Patients scheduled for routine clinical follow-up and/or right heart catheterization at the study center.
* Ability and willingness to provide informed consent for participation and data analysis.

Exclusion Criteria:

* Postcapillary pulmonary hypertension (pulmonary arterial wedge pressure \>15 mmHg).
* Conditions precluding safe blood sampling (e.g., severe anemia, coagulopathy).
* Patients already enrolled in interventional clinical trials that could interfere with mitochondrial or oxidative stress measurements
* Patients unable or unwilling to provide informed consent
* Pregnancy or breastfeeding

Where it's running

• Hôpitaux Universitaires de Strasbourg - Service Physiologie explorations fonctionnelles
  Strasbourg, Bas-Rhin, France Recruiting

Study contacts

• Principal investigator: Marianne RIOU — Hôpitaux Universitaires de Strasbourg
• Study coordinator: Marianne RIOU
• Email: marianne.riou@chru-strasbourg.fr
• Phone: + 33 3 69 55 11 45

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.