Registry for understanding BK virus in kidney transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of adaptive immunity in kidney transplant recipients who have been diagnosed with BK virus infection. It focuses on understanding the immune responses, particularly the role of T cells, in managing BK viremia and the impact of various treatment approaches, including immunosuppression reduction and intravenous immunoglobulins. The study will collect blood and urine samples from participants to analyze their immune responses and identify those at higher risk for developing complications related to BK virus infection. The cohort will primarily consist of high immunological risk kidney transplant recipients, including retransplant candidates and those with a history of desensitization therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult (\>18 years old) male and female, deceased donor KT recipients
* Will include single organ transplants.
* Each participant must also have recently been diagnosed with BK viremia.
* In addition to the aforementioned inclusion criteria, each participant in the sub-study must also have recently been diagnosed with BK viremia or have difficult-to-treat BKV \> 3 logs (BKV log does not decrease by more than 1 log copy/ml drop on second per protocol lab).

Exclusion Criteria:

* Prisoners will not be included in the study
* Multi-organ transplants and pregnant women

Where it's running

• Virginia Commonwealth University
  Richmond, Virginia, United States Recruiting

Study contacts

• Principal investigator: Ambreen Azhar — Virginia Commonwealth University
• Study coordinator: Ambreen Azhar
• Email: ambreen.azhar@vcuhealth.org
• Phone: 804-828-4104

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AIC263029 in kidney transplant recipients with BK virus infection

  This trial tests whether AIC263029 is safe and tolerable and can lower BK virus levels in adults who recently had a kidney transplant and have BK viremia, compared with placebo.

  Recruiting at 14 sites Phase 2 AiCuris Anti-infective Cures AG · Birmingham, Alabama and 13 other locations · NCT07503561

• Omnisol-preserved kidneys before transplant (hypothermic machine perfusion)

  This study tests whether using Omnisol during hypothermic machine perfusion before kidney transplant can improve early graft function compared with standard preservation.

  Recruiting Vivalyx GmbH · Rotterdam · NCT07792317

• How Propofol and Sevoflurane Affect miRNA in Living Kidney Donors

  This study tests whether using propofol or sevoflurane during donor nephrectomy changes levels of miRNAs in living kidney donors.

  Recruiting University of Gaziantep · Gaziantep, Sahinbey · NCT07760402

• Effects of general vs spinal-epidural anesthesia on kidney transplant biomarkers

  This study tests whether sevoflurane general anesthesia or combined spinal-epidural anesthesia changes markers of cellular stress and protective peptides in adults undergoing kidney transplantation.

  Recruiting University of Gaziantep · Gaziantep, State/Province · NCT07678073

• How kidney transplant patients feel about using artificial intelligence in medicine

  This international survey asks adults who have had a kidney transplant how they feel about AI tools that predict graft loss and what it might mean for their daily care.

  Recruiting at 2 sites Paris Translational Research Center for Organ Transplantation · Paris, Île-de-France Region and 1 other locations · NCT07600541

• Personalized therapeutic stories for children after kidney transplant.

  We will test whether clinician-supervised AI can create age-appropriate, personalized therapeutic stories for children aged 5–12 who have received a kidney transplant and their families.

  Recruiting Paris Translational Research Center for Organ Transplantation · Paris, Île-de-France Region · NCT07532382

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.