Bedtime device restriction plus desmopressin for bedwetting in kids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, open-label, randomized trial in Cairo, Egypt, enrolling 6- to 14-year-olds with primary monosymptomatic nocturnal enuresis. Participants are randomly assigned to receive desmopressin for 8 weeks with either bedtime digital-device restriction (at least 60 minutes before bed) or usual screen use, alongside standard clinical follow-up and dose adjustment. The study will measure the proportion with a full response (no more than one wet night in the last two weeks) and secondary outcomes such as weekly wet nights, partial response, sleep quality, adherence, and relapse four weeks after treatment ends. Baseline data will be collected to identify predictors of response. Outcomes will help determine if behavior modification around screen time enhances pharmacologic treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 6-14 years.
* Diagnosis of PMNE (≥2 wet nights/week for ≥6 months, no daytime symptoms, no prior sustained dryness \>6 months).
* Willingness to take oral desmopressin nightly for 8 weeks.
* Parent/guardian able to monitor and report screen time and wet nights.
* Written informed consent from parent/guardian and assent from child (if age-appropriate).

Exclusion Criteria:

* Secondary enuresis or non-monosymptomatic enuresis (daytime incontinence, urgency, frequency).
* Known organic causes (e.g., diabetes mellitus, urinary tract anomalies, neurological disorders).
* Current use of other enuresis treatments (alarms, anticholinergics, imipramine) within 4 weeks prior to enrollment.
* Severe sleep disorders (e.g., obstructive sleep apnea) or psychiatric conditions affecting compliance.
* Inability to comply with study procedures or follow-up.

Where it's running

• Department of Urology, Al-Hussein and Sayed Galal University Hospitals, Al-Azhar University
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Abul-fotouh Ahmed — Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
• Study coordinator: Abul-fotouh Ahmed
• Email: abulfotouhahmed@yahoo.com
• Phone: +201001066756

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.