Basilar artery occlusion with large brain infarct: real-world endovascular vs medical therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter retrospective registry collects data from patients treated in typical clinical practice. It compares safety and effectiveness of endovascular therapy against medical therapy for acute large-core basilar artery occlusion. The study analyzes clinical, imaging, and laboratory factors to identify associations with functional outcomes and mortality. Patients are grouped by the treatment they actually received in real-world settings. The setting is a Beijing-based hospital with multiple centers contributing data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years, men or women.
2. Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
3. Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.
4. Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.

Exclusion Criteria:

1. Subjects with occlusions in both anterior and posterior circulation.
2. CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).
3. Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).
4. Baseline NIHSS score \<6.
5. Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.
6. Missing follow-up outcomes at 90 days.
7. Any other condition judged by investigators to substantially affect analysis or interpretation.

Where it's running

• Xuanwu Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Chuanhui Li
• Email: lichuanhui@xwh.ccmu.edu.cn
• Phone: 15210439828

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.