Association Between Severe Periodontitis and Arterial Stiffness: The PAROCAR Study

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

PAROCAR is a monocentric, prospective cross-sectional study that compares arterial stiffness, measured by pulse wave velocity, between adults with generalized periodontitis stage 3-4 and matched controls without periodontitis. The study enrolls 206 participants aged 40-69, excluding those with diabetes, hypertension, major cardiovascular disease, high BMI, or recent periodontal treatment, among other criteria. Periodontal examinations and PWV measurements are performed to explore potential associations with conventional cardiovascular risk factors. The investigation aims to provide proof of concept for a contributory role of severe periodontitis in cardiovascular risk. Findings may inform future strategies linking oral health and cardiovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 40-69 years
* Minimum of 12 teeth (3 per quadrant)
* Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium

Exclusion Criteria:

* Patients diagnosed with diabetes,
* Patients diagnosed with hypertension or with a history of severe cardiovascular disease,
* Patients diagnosed with familial hypercholesterolaemia,
* Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results,
* Patients with a BMI ≥ 30 kg/m²,
* Patients who have previously undergone periodontal treatment,
* Patients who consume more than 2 units of alcohol per day,
* Patients who refuse to participate in the study,
* Minors and patients under the age of 40,
* Adult patients under legal protection (guardianship, curatorship),
* Patients deprived of their liberty,
* Pregnant or breastfeeding women,
* Patients not affiliated with a health insurance scheme (AME)
* Patients already included in another interventional study

Where it's running

• CHU de Nantes
  Nantes, France Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.