Assessing vaccine response in kidney transplant patients after COVID-19 vaccination
Official title: Immunological Follow-up After COVID 19 Vaccination in Kidney Transplant Recipients
Run by University Hospital, Strasbourg, France · NCT04757883 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how well kidney transplant patients respond to the COVID-19 vaccine to understand their immune reaction better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT04757883 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are kidney or pancreatic kidney transplant recipients who are at least 18 years old and have been transplanted for more than three months.
✕Probably not a fit
Patients with a history of anaphylactic shock to PEG, known COVID-19 infection within three months prior to vaccination, or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the immune response of kidney transplant recipients following their vaccination against SARS-CoV-2. Participants will include individuals who have undergone kidney transplantation for more than three months and are receiving the vaccine as part of routine care. The study will analyze both the humoral response by measuring neutralizing antibodies and the cellular response through specific assays. The goal is to better understand how this patient population responds to the COVID-19 vaccine.
Why it matters
Potential benefit: If successful, this study could provide insights into the effectiveness of COVID-19 vaccines in kidney transplant recipients, potentially guiding vaccination strategies for this vulnerable group.
How similar studies have gone: Other studies have shown varying responses to COVID-19 vaccines in immunocompromised populations, indicating that this area of research is both relevant and necessary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female, 18 years of age or older * Patient vaccinated against SARS-CoV-2 as part of routine care * Kidney or pancreatic kidney transplant * Transplantation for more than 3 months * Subject affiliated to a social protection health insurance * Subject able to understand the objectives and risks of the research and to give signed and dated informed consent Exclusion Criteria: * History of anaphylactic shock or known allergy to PEG * Known history of COVID or positive Covid serology in the 3 months prior to vaccination * Contraindication to an intramuscular injection * Impossibility to give informed information about the subject (subject in an emergency situation, difficulties in understanding the subject, ...) * Subject under safeguard of justice * Subject under guardianship
Where it's running
-
Caillard Sophie
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Sophie Caillard, MD
- Email: sophie.caillard@chru-strasboourg.fr
- Phone: 003388116768
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Diode laser–assisted gum treatment for people with kidney transplants
This project will test whether adding a diode laser to standard deep dental cleaning (scaling and root planing) helps people with periodontitis who have had a kidney transplant.
-
Faster versus controlled weight training after a kidney transplant
This trial will test whether doing resistance exercises quickly versus more slowly for 12 weeks improves kidney health, metabolic markers, and strength in adults who have had a kidney transplant.
-
Education on Immunosuppressive Therapy Reduction in Kidney Transplant Recipients in ICU with Sepsis or Respiratory Failure
In kidney transplant patients who are in the ICU for septic shock or severe respiratory failure, the study will test a targeted approach to adjust immunosuppressive therapy and provide education to support safer care.
-
Effects of exercise and diet on cardiovascular risk in kidney transplant patients
This study is testing if a personalized exercise and diet program can help kidney transplant patients lower their risk of heart problems over three years compared to standard care.
-
Extended-release tacrolimus to improve thinking and memory in older kidney transplant recipients
This will try switching older kidney transplant recipients from immediate-release tacrolimus to an extended-release formulation to see if it improves thinking, memory, or other cognitive symptoms.
-
Combination therapy of two diabetes medications in kidney transplant recipients
This study is testing if a combination of two diabetes medications can help kidney transplant recipients improve their kidney function and heart health.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.