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Clinical trial Recruiting at 1 site Observational Ages 40 to 80 Men only

Assessing prostate cancer tissue using a fine needle probe

Official title: Interstitial Assessment of Architectural Heterogeneity in Prostate Cancer Using a Fine Needle Photoacoustic Probe

Run by University of Michigan Rogel Cancer Center · NCT05965180 · Data updated 2026-11-12

This study is testing a new fine needle probe that uses light and sound to check for prostate cancer without taking tissue samples during biopsies.

Quick facts

Study typeObservational
Ages40 Years to 80 Years
SexMen only
Enrollment50 (estimated)
SponsorUniversity of Michigan Rogel Cancer Center
Academic / other
Locations1 site (Ann Arbor, Michigan)
StatusRecruiting
StartedOctober 16, 2023
Main results expectedOctober 2027
Study endsOctober 2027
Registry record updatedNovember 9, 2026
Trial IDNCT05965180 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are men aged 40 to 80 who are scheduled for a prostate biopsy as part of their routine clinical care.

Probably not a fit

Patients with bleeding disorders, those on anticoagulants, or individuals who cannot provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project integrates Photoacoustic (PA) technology into prostate biopsy procedures using a fine needle probe designed to work with transrectal ultrasound (TRUS). The probe will assess histological information from surrounding prostate tissue without extracting any samples. It has previously been tested on prostate tissue samples and whole human prostates in ex vivo conditions. The goal is to enhance the accuracy of prostate cancer assessments during routine biopsies.

Why it matters

Potential benefit: If successful, this approach could lead to more accurate diagnoses of prostate cancer without the need for tissue extraction.

How similar studies have gone: While this approach is innovative, similar studies using photoacoustic technology in other contexts have shown promise, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* 1\) Planned prostate biopsy as part of routine clinical care
* 2\) \> 40 and \<80 years old

Exclusion Criteria:

* 1\) Known history of bleeding disorders or
* 2\) Patients taking anticoagulants, no matter doses or washout time
* 3\) Known allergy to silicone material
* 4\) Unable to provide informed consent
* 5\) Either the surgeon or the patient do not think the patient will not be able to complete all parts of the study, the patient will be excluded
* 6\) Involved in other investigational studies.

Where it's running

  • University of Michigan Rogel Cancer Center
    Ann Arbor, Michigan, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Prostate Cancer 1464University of Michigan Rogel Cancer Center 40
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.