Assessing lung tumor motion with dynamic MRI
RealMove (Lung): Assessing Tumour Motion With Dynamic MRI
This study is testing if using dynamic MRI can better track lung tumor movement during breathing compared to standard 4D CT scans for patients getting targeted radiation therapy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Region Stockholm Government |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT06322329 on ClinicalTrials.gov |
What this trial studies
This study aims to improve the treatment of lung tumors by using dynamic MRI to assess tumor motion during the respiratory cycle. It compares the effectiveness of dynamic MRI against the standard 4D CT imaging in tailoring the safety margins for stereotactic body radiotherapy (SBRT). Patients receiving SBRT for lung tumors located below the carina will participate, undergoing both imaging techniques to evaluate tumor motion and its impact on treatment outcomes. The study also includes monitoring patient anxiety levels during imaging sessions to understand its influence on breathing patterns.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for SBRT treatment of lung tumors located below the carina.
Not a fit: Patients who are pregnant, breastfeeding, or have contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more precise radiotherapy treatments, minimizing damage to healthy tissues while effectively targeting tumor cells.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for tumor motion assessment, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Accepted for SBRT treatment of one or more caudally situated lung targets (NSCLC or metastases), i.e. below the carina. * Age ≥ 18 years * Adequate clinical condition to maintain immobilised position for at least 30 minutes * Adequate Swedish skills and cognitive function to understand study information and to fill in the questionnaire Exclusion Criteria: * Pregnancy or breastfeeding, or planned pregnancy or breastfeeding, during treatment * Contraindication for MRI examination * Otherwise incapable of participating in study
Where this trial is running
Stockholm
- Karolinska University Hospital — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: Eva Onjukka, PhD — Karolinska University Hospital/Karolinska Institutet
- Study coordinator: Mattias Hedman, MD PhD
- Email: mattias.hedman@regionstockholm.se
- Phone: +46812370000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.