Assessing how different head-of-bed elevations affect breathing mechanics in ventilated patients
Respiratory Mechanics Assessment at Different Head of the Bed Elevations in Mechanically Ventilated Patients
This study is testing how different angles of raising the head of the bed can improve breathing for patients on a ventilator.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Sao Paulo General Hospital Academic / other |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT06409897 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of various head-of-bed elevations on respiratory mechanics in patients undergoing invasive mechanical ventilation due to respiratory failure. Using advanced techniques such as electrical impedance tomography and esophageal and gastric balloon catheters, the research aims to identify the optimal angle for enhancing respiratory function. Patients will be monitored at different elevations (0, 10, 20, 30, and 40 degrees) to collect data on respiratory mechanics, hemodynamics, and arterial blood gases. The findings could lead to improved ventilation strategies in intensive care settings.
Who should consider this trial
Good fit: Ideal candidates are intubated patients under invasive mechanical ventilation due to respiratory failure.
Not a fit: Patients with hemodynamic instability or contraindications for the monitoring techniques used in this study may not benefit.
Why it matters
Potential benefit: If successful, this study could optimize mechanical ventilation strategies, potentially improving outcomes for patients with respiratory failure.
How similar studies have performed: While the specific approach of this study is novel, previous studies have explored head-of-bed elevation effects, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients under invasive mechanical ventilation, intubated due to respiratory failure Exclusion Criteria: * Hemodynamics instability, contraindication for monitoring with esophageal and gastric catheters, and Electrical impedance tomography, no authorization of medical team of the intensive care unit, and contraindication for lung recruitment maneuver
Where this trial is running
São Paulo
- Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP — São Paulo, Brazil (Recruiting)
Study contacts
- Principal investigator: Marcelo BP Amato, MD, PhD — University of Sao Paulo General Hospital
- Study coordinator: Marcelo BP Amato, MD, PhD
- Email: marcelo.amato@hc.fm.usp.br
- Phone: 3061-7361
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.