Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Assessing heart function and circulation in adults

Official title: A Novel Approach to the Assessment of the Systemic Circulation and Left Ventricular Performance in Adults

Run by University of Calgary · NCT04347655 · Data updated 2026-11-12

This study is testing new ways to check heart function and blood flow in adults with heart failure compared to healthy people to see how their hearts respond during a handgrip test.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity of Calgary
Academic / other
Locations1 site (Calgary, Alberta)
StatusRecruiting
StartedSeptember 15, 2021
Main results expectedDecember 31, 2028
Study endsDecember 31, 2029
Registry record updatedMay 5, 2026
Trial IDNCT04347655 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults aged 18 and older with clinical heart failure or healthy individuals without heart failure.

Probably not a fit

Patients who are unable or unwilling to provide informed consent or those on intravenous inotrope or pressor medications may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate cardiovascular function in adults by using novel concepts to assess systemic circulation and left ventricular (LV) performance. The researchers will compare patients with heart failure, both with reduced and preserved ejection fraction, to healthy controls using non-invasive methods. Participants will undergo a handgrip test while being monitored with EKG electrodes and finger blood pressure cuffs to gather real-time data on their cardiovascular responses. The study seeks to identify indicators of compromised heart function in patients with heart failure.

Why it matters

Potential benefit: If successful, this study could lead to improved assessment methods for heart failure, enhancing patient management and treatment outcomes.

How similar studies have gone: While this approach is novel in humans, similar concepts have shown promise in animal models, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 years or older
* Clinical heart failure (HFrEF or HFpEF) for heart failure patients and no clinical heart failure for the non-heart failure participants.

Exclusion Criteria:

* Unable or unwilling to provide informed consent
* On intravenous inotrope or pressor medications to maintain their cardiac function

Where it's running

  • University of Calgary
    Calgary, Alberta, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.