Assessing heart function and circulation in adults
Official title: A Novel Approach to the Assessment of the Systemic Circulation and Left Ventricular Performance in Adults
Run by University of Calgary · NCT04347655 · Data updated 2026-11-12
This study is testing new ways to check heart function and blood flow in adults with heart failure compared to healthy people to see how their hearts respond during a handgrip test.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Calgary Academic / other |
| Locations | 1 site (Calgary, Alberta) |
| Status | Recruiting |
| Started | September 15, 2021 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | May 5, 2026 |
| Trial ID | NCT04347655 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with clinical heart failure or healthy individuals without heart failure.
✕Probably not a fit
Patients who are unable or unwilling to provide informed consent or those on intravenous inotrope or pressor medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate cardiovascular function in adults by using novel concepts to assess systemic circulation and left ventricular (LV) performance. The researchers will compare patients with heart failure, both with reduced and preserved ejection fraction, to healthy controls using non-invasive methods. Participants will undergo a handgrip test while being monitored with EKG electrodes and finger blood pressure cuffs to gather real-time data on their cardiovascular responses. The study seeks to identify indicators of compromised heart function in patients with heart failure.
Why it matters
Potential benefit: If successful, this study could lead to improved assessment methods for heart failure, enhancing patient management and treatment outcomes.
How similar studies have gone: While this approach is novel in humans, similar concepts have shown promise in animal models, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Clinical heart failure (HFrEF or HFpEF) for heart failure patients and no clinical heart failure for the non-heart failure participants. Exclusion Criteria: * Unable or unwilling to provide informed consent * On intravenous inotrope or pressor medications to maintain their cardiac function
Where it's running
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University of Calgary
Calgary, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Satish R Raj, MD MSCI — University of Calgary
- Study coordinator: Rasha Hamzeh, RN
- Email: autonomic.research@ucalgary.ca
- Phone: 4032208897
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.