Assessing heart disease risk in former NFL players
Official title: Using CTA Measures to Define Cardiac Risk In NFL Alumni
Run by HeartFlow, Inc. · NCT06831409 · Data updated 2026-11-12
This study looks at heart disease risk in retired NFL players by checking their heart health with special scans to see how their past as professional athletes affects them.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | HeartFlow, Inc. Industry-sponsored |
| Locations | 1 site (Greenwood Village, Colorado) |
| Status | Recruiting |
| Started | December 17, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 26, 2025 |
| Trial ID | NCT06831409 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are retired NFL players who have previously been on a practice squad or active roster.
✕Probably not a fit
Patients who are not retired NFL players or those whose coronary computed tomography angiography cannot be successfully processed will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The GAMEFILM Registry is a multi-center observational study that collects data on the prevalence and severity of coronary artery disease (CAD) among retired NFL players. This study involves approximately 300 participants from around 20 sites across the United States. Participants will undergo coronary computed tomography angiography to evaluate their cardiac health and identify potential risks associated with their history as professional athletes.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the cardiac health of former NFL players, leading to better prevention and treatment strategies for heart disease.
How similar studies have gone: Other studies have explored cardiac health in athletes, but this specific focus on retired NFL players and the use of advanced imaging techniques is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Retired NFL player Exclusion Criteria: * CCTA not successfully processed for FFRct and AI-Plaque
Where it's running
-
Boone Heart Institute
Greenwood Village, Colorado, United States Recruiting
Study contacts
- Principal investigator: Jeffrey Boone — Boone Heart Institute
- Study coordinator: HeartFlow
- Email: GAMEFILM@heartflow.com
- Phone: 650-241-1221
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.