Clinical trial Recruiting at 1 site Observational

Assessing heart disease risk in former NFL players

Official title: Using CTA Measures to Define Cardiac Risk In NFL Alumni

Run by HeartFlow, Inc. · NCT06831409 · Data updated 2026-11-12

This study looks at heart disease risk in retired NFL players by checking their heart health with special scans to see how their past as professional athletes affects them.

Quick facts

Study typeObservational
SexAll
Enrollment300 (estimated)
SponsorHeartFlow, Inc.
Industry-sponsored
Locations1 site (Greenwood Village, Colorado)
StatusRecruiting
StartedDecember 17, 2024
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedAugust 26, 2025
Trial IDNCT06831409 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are retired NFL players who have previously been on a practice squad or active roster.

Probably not a fit

Patients who are not retired NFL players or those whose coronary computed tomography angiography cannot be successfully processed will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The GAMEFILM Registry is a multi-center observational study that collects data on the prevalence and severity of coronary artery disease (CAD) among retired NFL players. This study involves approximately 300 participants from around 20 sites across the United States. Participants will undergo coronary computed tomography angiography to evaluate their cardiac health and identify potential risks associated with their history as professional athletes.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the cardiac health of former NFL players, leading to better prevention and treatment strategies for heart disease.

How similar studies have gone: Other studies have explored cardiac health in athletes, but this specific focus on retired NFL players and the use of advanced imaging techniques is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Retired NFL player

Exclusion Criteria:

* CCTA not successfully processed for FFRct and AI-Plaque

Where it's running

  • Boone Heart Institute
    Greenwood Village, Colorado, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.