Assessing genetic and molecular profiles in health and disease in the Czech population
Assesment of Multiomics Profiles in Health and Disease - Corelation With the Disease Phenotype.
This study is trying to gather genetic and health information from 10,000 people in the Czech Republic, both healthy and those with diseases, to help better understand health issues in the region.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1100 (estimated) |
| Ages | 18 Years to 68 Years |
| Sex | All |
| Sponsor | The Institute of Molecular and Translational Medicine, Czech Republic Academic / other |
| Locations | 1 site (Olomouc) |
| Trial ID | NCT04427163 on ClinicalTrials.gov |
What this trial studies
This observational study aims to establish reference genomic, transcriptomic, proteomic, and metabolomic profiles within the Czech population. Initially involving 1,000 healthy volunteers, the study plans to expand to 10,000 participants, including both healthy individuals and patients with various diseases. By creating a comprehensive reference database, the study seeks to enhance the interpretation of pathological findings in patients, particularly in the context of the unique genetic and environmental factors present in Central Europe. Participants will also have the opportunity to contribute biological samples for future research.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals aged 18 to 68 without a genetic predisposition to disease or significant health issues.
Not a fit: Patients with existing genetically dependent diseases or significant health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into disease predisposition and improve disease diagnosis and management for patients.
How similar studies have performed: While similar studies have been conducted in other populations, this approach is novel for the Czech and Slavic populations, making it a unique contribution to the field.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age 18 - 68 years * (for the first 1100 subjects): * healthy volunteers without genetically dependent disease and without such a disease in a family * healthy volunteer without the preliminary evidence of civilizational diseases such as hypertension, diabetes, autoimmune and tumor diseases or acute infectional diseases; clinically manifesting cardiovascular or pulmonary disability. * subject without permanent of long-term medication in the time of biological sampling. Exclusion Criteria: * not complying with inclusion criteria
Where this trial is running
Olomouc
- University Hospital Olomouc — Olomouc, Czechia (Recruiting)
Study contacts
- Study coordinator: Marian Hajduch, MD, PhD.
- Email: marian.hajduch@upol.cz
- Phone: +420585632083
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.