Assessing cognitive function in brain tumor patients after radiation therapy
Official title: Cognitive Function After Radiation Therapy for Primary Brain Tumours
Run by University of Aarhus · NCT04306432 · Data updated 2026-11-12
This study is trying to see how radiation therapy affects thinking skills over time in patients with primary brain tumors, except glioblastoma, by checking their cognitive function at different points after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of Aarhus Academic / other |
| Drugs / interventions | radiation |
| Locations | 5 sites (Copenhagen, Capital Region and 4 other locations) |
| Status | Recruiting |
| Started | January 3, 2019 |
| Main results expected | March 31, 2034 |
| Study ends | March 31, 2034 |
| Registry record updated | December 2, 2021 |
| Trial ID | NCT04306432 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Danish-speaking adults aged 18 and older with specific types of primary brain tumors, excluding glioblastoma.
✕Probably not a fit
Patients with glioblastoma or those with a performance status of 3-4 will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates cognitive function in patients with primary brain tumors who have undergone radiation therapy. It aims to identify the relationship between radiation dose and cognitive impairment by assessing patients at multiple time points: before treatment and at 1, 3, 5, and 10 years post-treatment. A comprehensive battery of standardized cognitive tests and patient-reported outcomes will be utilized to gather data on cognitive performance and quality of life. The study includes various types of brain tumors, excluding glioblastoma, and is conducted across multiple centers in Denmark.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive impairments in brain tumor patients receiving radiation therapy.
How similar studies have gone: While studies on cognitive function post-radiation exist, this study's specific focus on dose-response relationships in various brain tumor types is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older and Danish speaking. * Performance status WHO 0-2 * Capable of cooperating on testing * Tumour histology (WHO 2016 classification) of the following types: anaplastic astrocytoma (IDH mutant), diffuse astrocytoma (IDH-mutant), gemistocytic astrocytoma (IDH mutant), diffuse astrocytoma (NOS), oligodendroglioma, meningioma, medulloblastoma (NOS), pituitary adenoma, other brain tumours including skull base sarcomas Exclusion Criteria: * Glioblastoma * Performance status 3-4 (Karnofsky Performances of 60 or less)
Where it's running
-
Department of Oncology, Rigshospitalet
Copenhagen, Capital Region, Denmark Recruiting -
Danish Center for Particel Therapy
Aarhus, Region Midt, Denmark Recruiting -
Department of Oncology, Aarhus University Hospital
Aarhus, Region Midt, Denmark Recruiting -
Department of Oncology, Aalborg University Hospital
Aalborg, Region Nord, Denmark Recruiting -
Department of Oncology, Odense University Hospital
Odense, Region Syd, Denmark Recruiting
Study contacts
- Principal investigator: Lene Haldbo-Classen, M.D — Aarhus University Hospital
- Study coordinator: Morten Høyer, MD
- Email: morthoey@rm.dk
- Phone: +45 2328 2823
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.