Assessing brain function during cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify risk factors for neurological complications associated with cardiac surgery by conducting a comprehensive assessment of patients before, during, and after the surgical procedure. It involves detailed evaluations of medical histories and cerebral function preoperatively, real-time monitoring of cerebral blood flow and oxygenation intraoperatively, and postoperative assessments for cognitive dysfunction and other complications. The goal is to develop a predictive model that enhances clinical decision-making and improves patient safety by reducing the incidence of neurological complications.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Age 18-80 years;
2. Patients undergoing cardiovascular surgical procedures;
3. Able to understand and comply with the clinical trial protocol requirements, and willing to sign the informed consent form.

Exclusion Criteria:

1. Inability to tolerate required diagnostic procedures, including neck CT angiography (CTA), head CT perfusion (CTP), or electroencephalography (EEG), due to underlying physical limitations or medical contraindications;
2. Severe renal insufficiency, characterized by a creatinine clearance of less than 30 mL/min (using the Cockcroft-Gault formula), serum creatinine levels exceeding twice the upper limit of normal, or any other form of clinically significant renal impairment;
3. Severe hepatic dysfunction, defined by ALT or AST levels greater than three times the upper limit of normal, or the presence of hepatic conditions such as acute or chronic hepatitis, cirrhosis, or other significant liver disorders;
4. Comorbid conditions that may compromise study participation or pose substantial risk to the patient, including, but not limited to, alcohol or substance abuse, malignancies, and severe diseases affecting the liver, kidneys, lungs, endocrine system (e.g., uncontrolled diabetes or thyroid disorders), or hematopoietic system;
5. Inability to cooperate with study procedures, whether due to cognitive, psychological, or physical factors that would impede compliance with protocol requirements;
6. Other conditions deemed unsuitable by the investigator, including any medical or non-medical factors that, in the investigator's assessment, may preclude safe or effective participation in the study.

Where it's running

• Department of Neurology, Fuwai Hospital, Chinese Academy of Medical Sciences
  Beijing, China Recruiting

Study contacts

• Study coordinator: Yao Feng, Dr.
• Email: fengyao_dr@sina.com
• Phone: 18810643595

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Impact of Fast-Track Anesthesia on Postoperative Delirium After Cardiac Surgery

  This observational study tests whether fast-track anesthesia, compared with conventional care, is linked to lower rates of delirium after elective cardiac surgery in adults.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jiangxi · NCT07923344

• Sarcopenia in Patients After Cardiac Surgery

  This observational study tests how common sarcopenia is after cardiac surgery and whether current care helps improve muscle mass and function.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07908472

• Preoperative functional optimization for adults undergoing major cardiac or abdominal surgery

  This study tests a four‑week prehabilitation program to improve fitness before elective major cardiac or abdominal surgery.

  Recruiting ASST Sette Laghi · Varese, VA and 1 other locations · NCT07851350

• Oral Extubation Right After Cardiac Surgery

  This trial tests whether waking patients and removing the breathing tube in the operating room after elective cardiac surgery helps recovery more quickly without added risk.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07757880

• Frailty and Ultrasound-Guided Catheterization in Adult Cardiac Surgery Patients

  This study tests whether frailty and ultrasound measurements taken before surgery can predict how difficult it will be to place an ultrasound-guided internal jugular venous catheter in adults undergoing elective cardiac surgery.

  Recruiting Ankara City Hospital Bilkent · Ankara, Ankara · NCT07701538

• Prehabilitation before heart surgery for adults with congenital heart disease

  This study is testing whether a tailored, supervised exercise program before heart surgery helps adults with congenital heart disease perform better and improve fitness.

  Recruiting Liverpool Heart and Chest Hospital NHS Foundation Trust · Liverpool · NCT07700459

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.