Analyzing genetic mutations in papillary thyroid tumors
Caratterizzazione Del Profilo Mutazionale Nel Tumore Papillare Della Tiroide Tramite Tecnologia Mass-ARRAY
This study is trying to see if analyzing genetic changes in thyroid tumors can help doctors understand the disease better and find better treatments for patients with papillary thyroid cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Sex | All |
| Sponsor | Istituto Auxologico Italiano Academic / other |
| Locations | 1 site (Milan, MI) |
| Trial ID | NCT05766098 on ClinicalTrials.gov |
What this trial studies
This observational study aims to characterize the mutational profile of papillary thyroid carcinomas (PTC) by analyzing tumor samples using a specialized Mass ARRAY platform. The study focuses on identifying common somatic mutations in the MAP kinase pathway, which are present in a significant percentage of PTC cases. By correlating the molecular profiles with clinical and prognostic characteristics, the research seeks to enhance understanding of the disease and inform targeted therapies. The approach is sensitive, rapid, and cost-effective, allowing for comprehensive genetic analysis in a single experiment.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with papillary thyroid cancer who have tumor tissue available for genetic analysis.
Not a fit: Patients who have not consented to participate or whose tumor samples are unsuitable for genetic analysis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic assessments and personalized treatment strategies for patients with papillary thyroid cancer.
How similar studies have performed: Other studies have shown success in utilizing molecular characterization techniques for cancer profiling, indicating that this approach is promising and not entirely novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with papillary thyroid cancer * patients whose tumor tissue can be recovered for genetic analysis Exclusion Criteria: * patients who did not give consent * patients lost to follow-up * tumor samples not suitable for genetic analysis
Where this trial is running
Milan, MI
- Istituto Auxologico Italiano — Milan, Mi, Italy (Recruiting)
Study contacts
- Principal investigator: Laura Fugazzola, MD PhD — Istituto Auxologico Italiano-Milan, Italy
- Study coordinator: Marina Muzza, PhD
- Email: m.muzza@auxologico.it
- Phone: +390261191
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.