Benefits of Carbon Nanoparticles Injection Timing in Thyroid Cancer Treatment
Official title: A Comparative Study of Preoperative and Intraoperative Carbon Nanoparticles Injection in Patients Undergoing Thyroid Cancer Surgery
Run by Second Affiliated Hospital of Xi'an Jiaotong University · NCT06791005 · Data updated 2026-11-12
This study tests whether giving carbon nanoparticles before or during surgery can help people with papillary thyroid cancer have better outcomes and fewer complications.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 16 Years to 80 Years |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Second Affiliated Hospital of Xi'an Jiaotong University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Xi'an, Shaanxi) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | June 30, 2025 |
| Study ends | September 30, 2025 |
| Registry record updated | January 24, 2025 |
| Trial ID | NCT06791005 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with a confirmed diagnosis of papillary thyroid cancer, requiring total thyroidectomy, and with tumors less than 4 cm in diameter.
✕Probably not a fit
Patients with a history of prior thyroid surgery, those under 16 years of age, or individuals with certain tumor characteristics may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical study investigates the timing of carbon nanoparticles injection in patients undergoing surgery for papillary thyroid cancer. Participants will receive injections either preoperatively or intraoperatively to assess the impact on surgical outcomes and complications. The study aims to minimize common postoperative complications such as hypoparathyroidism and recurrent laryngeal nerve injury. By utilizing ultrasound guidance for precise injection, the research seeks to improve the safety and effectiveness of thyroid cancer surgeries.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative complications and improve the quality of life for patients with thyroid cancer.
How similar studies have gone: While the use of carbon nanoparticles in surgical settings is emerging, this specific approach to timing and application in thyroid cancer treatment is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Preoperative pathological assessment indicated the presence of thyroid cancer with a maximum diameter of less than 4 cm. * Postoperative pathological evaluation confirmed bilateral thyroid cancer or lateral lymph node metastasis. * Vocal cord examination conducted one week prior to surgery revealed no abnormalities. * The patient had no history of prior thyroid surgery and required a total thyroidectomy. * Blood pressure was stably controlled. * The patient regained consciousness and was able to communicate normally. Exclusion Criteria: * Prior to enrollment, the patient had received radiotherapy, chemotherapy, or isotope therapy. * A documented history of thyroid surgery. * Age under 16 years. * Known allergies to the medications under investigation or an inability to tolerate surgical intervention. * Presence of a retrosternal thyroid tumor. * Tumor invasion of the parathyroid glands and/or the recurrent laryngeal nerve during surgical procedures. * Postoperative pathology suggestive of medullary carcinoma or undifferentiated carcinoma. * Development of a postoperative tracheal fistula.
Where it's running
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The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China Recruiting
Study contacts
- Study coordinator: Yang Liu, doctor
- Email: individualliu@163.com
- Phone: 0086+029-13384986500
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.