Analysis of exosomes and single-cell data in gastric cardia cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze the heterogeneity of gastric cardia cancer by utilizing a case-control design. Patients with confirmed gastric cancer will be matched with controls based on age and gender. Researchers will collect clinical information and biological samples, including serum and tissue, to perform exosome sequencing, proteomics, and single-cell RNA sequencing. The goal is to identify specific biomarkers and potential therapeutic targets, which could lead to the development of new diagnostic tools and treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Study population signing informed consent form
* Age: 18 years old or older
* The study population must underwent endoscopic examination and was confirmed by pathological diagnosis as gastric cancer: including high-level intraepithelial neoplasia, early gastric cancer, and advanced gastric cancer.

Exclusion Criteria:

* Those who have undergone gastrointestinal surgery within the past 1 year; Patients who have undergone neoadjuvant chemotherapy and have developed tumors in the residual stomach after previous partial gastrectomy.
* Those who have used proton pump inhibitors, antibiotics, probiotics, and prebiotics daily within the past month, and those who have recently received hormone therapy.
* People with infectious diseases and other digestive system diseases that interfere with the experimental results, such as inflammatory bowel disease, irritable bowel syndrome, etc.

Where it's running

• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Xiaoya Wang, Bachelor
• Email: xiaoyawang99@163.com
• Phone: (86)13821379210

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.