Altered Joint Mechanics and Biological Response in Osteoarthritic Knees

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial investigates the effects of corrective knee treatments—bracing or high tibial osteotomy—on subchondral bone microstructure and cartilage in adults with early to moderate knee OA and limb misalignment. Participants will undergo advanced imaging (photon counting CT and MRI) and gait analysis to characterize structural and functional changes. The study is conducted at KU Leuven, enrolling individuals who will receive the planned corrective intervention and have follow-up at the same center. The goal is to better understand why some patients experience treatment failure and how to optimize correction. Safety monitoring and eligibility criteria ensure participants can complete imaging and follow-up assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.
* Chronic symptoms of (early) knee OA.
* Misalignment of the lower limb and scheduled for HTO surgery (regardless of the HTO technique used (lateral or medial, closing or opening wedge)) or brace treatment.
* Follow-up at UZ Leuven.

Exclusion Criteria:

* Acute OA symptoms onset (previous knee injury)
* Pregnant women
* MRI checklist incomplete or failed
* BMI \> 30
* Impaired vision or neurological condition that affect coordination and balance
* Age \<18 (no minors will be included in the study)

Where it's running

• Universitaire Ziekenhuizen KU Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Harry van Lenthe, Prof. Ir. — Universitaire Ziekenhuizen KU Leuven
• Study coordinator: Harry van Lenthe, Prof. Ir.
• Email: harry.vanlenthe@kuleuven.be
• Phone: +32 16 32 25 95

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.