Advanced respiratory monitoring to help safer ventilation in ICU patients without respiratory failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adults 18 and older who are invasively ventilated for conditions such as coma, trauma, or sepsis. Monitoring includes continuous airway and esophageal pressure, flow measurements, and lung ventilation distribution to tailor ventilation settings. The goal is to see if applying these monitoring techniques in patients without initial respiratory failure can reduce the risk of developing ARDS and related complications. Data from this single-site initiative at Humanitas Research Hospital will help determine feasibility and potential impact on ventilator strategy. The study does not assign a treatment but observes outcomes associated with enhanced monitoring practices.

Why it matters

Who can join: the full rules

Study Population Eligibility Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No

Inclusion Criteria:

Adult patients +18 years. Undergoing invasive mechanical ventilation for reasons other than acute respiratory failure (such as coma, trauma, or sepsis).

Initiation of monitoring within 24 hours of oro-tracheal intubation.

Exclusion Criteria:

Evidence of pneumothorax, pneumomediastinum, or subcutaneous emphysema. Pregnancy. Absolute contraindications to nasogastric tube placement. Absolute contraindications to electrical impedance tomography (EIT) monitoring.

Where it's running

• Humanitas Research Hospital
  Milan, Lombardy, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.