Full-Course ECMO Pathway for Moderate-to-Severe ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, real-world study develops a standardized, evidence-based full-course ECMO management pathway covering assessment, initiation, maintenance, weaning, and rehabilitation for adults with moderate-to-severe ARDS. It then compares patient outcomes before and after implementing the pathway across participating centers, using a before-and-after design. A closed-loop system will continually optimize the pathway based on data and updated guidelines. The goal is to reduce practice heterogeneity, improve weaning success, and lower complication rates during ECMO care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Age 18 years or older. 2. Diagnosed with moderate-to-severe acute respiratory distress syndrome according to the global definition of ARDS.

Exclusion Criteria:

\- 1. Patients with tracheostomy before screening. 2. Patients who have received lung transplantation or are receiving venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation.

3\. Patients with cardiogenic shock requiring venoarterial ECMO or venoarterial-venous ECMO support.

Where it's running

• Beijing Anzhen Hospital, Capital Medical University
  Beijing, China Recruiting
• The Second Affiliated Hospital of Dalian Medical University
  Dalian, China Recruiting
• Fuzhou University Affiliated Provincial Hospital
  Fuzhou, China Recruiting
• The First Affiliated Hospital of Guangzhou Medical University
  Guangzhou, China Recruiting
• The Second Affiliated Hospital of Zhejiang University School of Medicine
  Hangzhou, China Recruiting
• The Second Affiliated Hospital of Harbin Medical University
  Ha’erbin, China Recruiting

Study contacts

• Study coordinator: yingzi Huang, M.D.
• Email: yz_huang@126.com
• Phone: 18271428804

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Height measurement methods to guide ventilator settings in ARDS

  We’re testing whether more precise height measurements change how researchers set lung-protective tidal volumes in adults with ARDS who are on a ventilator.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07595926

• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07511582

• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07450846

• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

  This trial tests whether IV umbilical‑cord mesenchymal stem cells, alone or with secretome, help adults with severe ARDS recover lung function and reduce inflammation.

  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

• Human umbilical cord mesenchymal stem cell injection for moderate to severe ARDS

  This will test whether a single injection of human umbilical cord mesenchymal stem cells can help adults with moderate to severe ARDS that hasn't improved after standard treatment.

  Recruiting Phase 1/2 Changchun Tuohua Pharmaceutical Co., Ltd. · Wuhan, Hubei · NCT07413978

• PrismaLung+ carbon dioxide removal for ventilated ICU patients

  This study will test whether adding PrismaLung+, a device that removes CO2 from the blood, helps adults on invasive mechanical ventilation who have high carbon dioxide levels.

  Recruiting at 9 sites Vantive Health LLC · Beijing, Beijing Municipality and 9 other locations · NCT07326215

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.