Acellular Dermal Matrix vs. Resorbable Collagen Barrier for Guided Bone Regeneration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This investigator-initiated trial tests two barrier membranes—acellular dermal matrix (ADM) and resorbable cross-linked collagen matrix (Mem-Lok)—as part of guided bone regeneration at lateral ridge augmentation sites. Participants must be adults requiring horizontal ridge augmentation without immediate implant placement and meet specific health and dental criteria. Outcomes focus on hard- and soft-tissue results, including ridge width gains and tissue characteristics, using standardized GBR techniques with particulate grafts and barrier membranes. The study builds on prior data suggesting stable clot formation and space maintenance, while exploring potential additional soft-tissue benefits with ADM. Direct comparative data between ADM and collagen membranes in this context are limited, making this trial a key step in understanding relative performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* English speaking
* At least 18 years old
* Must be a patient of the UAB Dental School
* Able to read and understand informed consent document
* Patients presenting with a diagnosed need horizontal ridge augmentation with GBR without simultaneous implant placement, to allow for future dental implant placement.
* Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the edentulous span planned for GBR, or unhealthy adjacent teeth to be extracted during the same visit.
* ≤4 mm ridge width in a Seibert Class I Edentulous span19
* No anticipated need for surgical and/or endodontic care at planned teeth adjacent to the proposed surgical site during the study period.

Exclusion Criteria:

* Non-English speaking
* Less than 18 years old
* Smokers/nicotine users (defined as currently reporting use of any form of tobacco/nicotine products)
* Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing, including:

  * Uncontrolled diabetes (HbA1c \> 7%)
  * Untreated periodontal disease
  * History of head/neck radiation
  * IV bisphosphonates
  * Immunocompromised state
  * Pregnancy
  * Acute infection at site
* Documented or suspected allergy or sensitivity to any study product

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Maria L Geisinger, DDS, MS — University of Alabama at Birmingham
• Study coordinator: Maria Geisinger, DDS, MS
• Email: miagdds@uab.edu
• Phone: 205-934-4984

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.