Treatment options for Dupuytren's contracture
Official title: Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial
Run by Regionshospitalet Silkeborg · NCT05440240 · Data updated 2026-11-12
This study is testing whether adding a corticosteroid injection to a needle treatment helps people with Dupuytren's contracture move their fingers better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 45 Years to 99 Years |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Regionshospitalet Silkeborg Academic / other |
| Locations | 1 site (Silkeborg) |
| Status | Recruiting |
| Started | January 10, 2023 |
| Main results expected | December 2025 |
| Study ends | March 2030 |
| Registry record updated | May 17, 2023 |
| Trial ID | NCT05440240 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with Dupuytren contracture exhibiting a passive extension deficit of 20° or more in the metacarpophalangeal joint.
✕Probably not a fit
Patients with isolated proximal interphalangeal or distal interphalangeal joint contractures, or those with previous hand surgery on the affected finger, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial compares the effectiveness of percutaneous needle fasciotomy with and without corticosteroid injection for treating Dupuytren's contracture affecting the metacarpophalangeal joints. It is a multicenter, randomized controlled trial designed to assess the outcomes of these interventions. Participants will be evaluated based on their passive extension deficit to determine the success of the treatment. The study aims to provide insights into the best approach for managing this condition.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients suffering from Dupuytren's contracture.
How similar studies have gone: Other studies have shown promise in using percutaneous needle fasciotomy for Dupuytren's contracture, indicating that this approach is not entirely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Sufficient correction of metacarpophalangeal (MCP) joint during the PNF treatment, defined as \<20° passive extension deficit (PED), is a prerequisite for inclusion. Inclusion Criteria: * Dupuytren contracture (DC) of ≥ 20° PED in MCP joint measured with a goniometer * DC of either II-V finger * Well-defined/palpable cord Exclusion Criteria: * Legally incapacitated * Previous study inclusion with another finger ray * Isolated proximal interphalangeal (PIP) or distal interphalangeal (DIP) joint contracture, defined as MCP joint contracture \< 20° PED regardless of the deficit in the PIP or DIP joint * Previous hand surgery of the affected finger for any reason * Known allergy to the study medication * Anticoagulant therapy (Acetylsalicylic acid is NOT an exclusion criterion) * Pregnant or lactation * Insulin dependent diabetes mellitus * Ongoing systemic infection or local infection at the site of the procedure * Rheumatoid arthritis * Amyloidosis or mucopolysaccharidosis * Unable to communicate, cooperate or participate in follow-up
Where it's running
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Silkeborg Regional Hospital
Silkeborg, Denmark Recruiting
Study contacts
- Study coordinator: Laura H Matthiesen, MS, PhD-student
- Email: lather@rm.dk
- Phone: 004561281917
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.