Abnormally Fertilized Embryos: Does Chromosomal Content Stay Balanced in IVF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will analyze about 300 embryos from IVF cycles with abnormal pronuclear patterns (1PN, 2.1PN, 3PN) to determine their diploidy rate and potential parental origin of chromosomal gains or losses. Researchers will use PGT-A and related genetic analyses, along with morphokinetics data, to see if non-diploid embryos can have a normal chromosomal complement. Embryos that reach the blastocyst stage will be evaluated for euploidy, haploidy, or triploidy and, when possible, the origin of chromosomal abnormalities. Participation does not require additional visits beyond standard IVF/ICSI care and relies on samples collected during routine treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ART patients who sign the Informed Consent of the study.
* Age: oocytes from women ≤ 49 years and semen from men ≤ 60 years. Donation of gametes is allowed.
* ≥1 blastocysts from oocytes with an abnormal pronuclear pattern (1PN, 2.1PN, and/or 3PN) and with the presence of 2 polar bodies (PB), cultured in a time-lapse incubator.

Exclusion Criteria:

* No exclusion criteria have been considered for this study.

Where it's running

• Equipo Médico Crespo Valencia
  Valencia, Valencia, Spain Recruiting

Study contacts

• Principal investigator: Pere Mir Pardo, PhD — Igenomix
• Study coordinator: Carlos A Gomez De La Cruz, BSc MSc
• Email: carlos.gomez@igenomix.com
• Phone: +34963905310

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.