Using stereotactic radiosurgery to treat essential tremor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to evaluate the effectiveness of stereotactic radiosurgery in adult patients diagnosed with essential tremor who have not achieved sufficient tremor control with pharmacotherapy. Participants will be randomly assigned to receive either a higher or lower dose of radiation using the CyberKnife system. The study will assess both the effectiveness of the treatment and its impact on patients' quality of life, while also monitoring for safety and potential complications. Eligible patients are those over 50 years old with a diagnosis of essential tremor lasting more than five years.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Essential tremor diagnosed, Parkinson's disease and other causes of tremor excluded.
* Insufficient tremor control despite the use of available pharmacotherapy methods.
* Disqualification from the Deeply Brain Stimualtion procedure/lack of consent to perform it on the side qualified for Stereotactic Radiosurgery
* Consent to participate in a clinical trial.

Exclusion Criteria:

* Age under 50
* Pregnancy
* Duration of the disease less than 5 years
* Dementia, psychosis or other condition that prevents giving informed consent to participate in the study
* Poor general condition, serious comorbidities
* Structural changes in the basal ganglia or major atrophic changes
* Previous radiotherapy to the brain covering the potential treatment area
* Medical contraindications to magnetic resonance imaging

Where it's running

• Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch
  Gliwice, Poland Recruiting

Study contacts

• Principal investigator: Aleksandra Napieralska — Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch
• Study coordinator: Aleksandra Napieralska
• Email: aleksandra.napieralska@gliwice.nio.gov.pl
• Phone: 48322788056

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Encora X1 in Daily Life for Essential Tremor

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• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

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• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

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  Recruiting Lund University · Lund, Skåne County · NCT07820189

• Non-Invasive Nerve Stimulation for Essential Tremor: Long-Term Safety and Effectiveness

  This study tests whether a non-invasive stimulation device called TAPS helps reduce tremor in adults with essential tremor over a long period.

  Recruiting Ruijin Hospital · Shanghai · NCT07774598

• Low Intensity Focused Ultrasound for Essential Tremor in Adults

  This early-stage, open-label study tests whether repeated low-intensity focused ultrasound can safely and briefly modulate tremor in people with essential tremor.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT07599592

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.