Endothelial ROS in Exercise and Muscle Metabolism
Official title: Endothelial Reactive Oxygen Species in Exercise Metabolism
Funded at Virginia Polytechnic Inst and St Univ · NIH-11395211 · Data updated 2026-11-12
This grant explores how reactive oxygen species produced by blood vessel cells during exercise help muscles adapt and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | August 18, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $627,072 |
| NIH project number | 5R01AR083948-02 |
| Project ID | NIH-11395211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals interested in exercise and muscle health who would benefit from better understanding of how ROS signaling supports metabolic adaptation.
✕Less likely to help
People with conditions or circumstances that do not involve skeletal muscle metabolism or exercise adaptation may see limited direct benefit.
What this research studies
The research looks at how different muscle cell types talk to each other when you exercise, focusing on the role of reactive oxygen species produced by endothelial cells. It aims to map where ROS come from, which enzymes make them, and how they drive beneficial signaling that improves energy use in muscles. The study builds on prior work and uses the NOX4 enzyme as a key focus to understand how ROS influence endurance, metabolism, and health outcomes. The long-term goal is to translate these insights into strategies that prevent or manage metabolic diseases through exercise.
Why it matters
Potential benefit: If successful, the findings could guide new exercise-based approaches to improve muscle metabolism and prevent related diseases.
How similar studies have gone: Previous work suggests ROS have signaling roles in exercise adaptation, supporting potential benefits of this approach.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Craige, Siobhan M — Virginia Polytechnic Inst and St Univ
- Study coordinator: Craige, Siobhan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.